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Page 1
Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress.
Landspersky T, Saçma M, Rivière J, Hecker JS, Hettler F, Hameister E, Brandstetter K, Istvánffy R, Romero Marquez S, Ludwig R, Götz M, Buck M, Wolf M, Schiemann M, Ruland J, Strunk D, Shimamura A, Myers K, Yamaguchi TP, Kieslinger M, Leonhardt H, Bassermann F, Götze KS, Geiger H, Schreck C, Oostendorp RAJ. Landspersky T, et al. Among authors: sacma m. Blood. 2022 Feb 3;139(5):690-703. doi: 10.1182/blood.2021011775. Blood. 2022. PMID: 34657154 Free PMC article.
Exercise generates immune cells in bone.
Saçma M, Geiger H. Saçma M, et al. Nature. 2021 Mar;591(7850):371-372. doi: 10.1038/d41586-021-00419-y. Nature. 2021. PMID: 33627859 No abstract available.
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H. Guidi N, et al. Among authors: sacma m. EMBO J. 2017 Apr 3;36(7):840-853. doi: 10.15252/embj.201694969. Epub 2017 Mar 2. EMBO J. 2017. PMID: 28254837 Free PMC article.
Aging alters the epigenetic asymmetry of HSC division.
Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H. Florian MC, et al. Among authors: sacma m. PLoS Biol. 2018 Sep 20;16(9):e2003389. doi: 10.1371/journal.pbio.2003389. eCollection 2018 Sep. PLoS Biol. 2018. PMID: 30235201 Free PMC article.
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift.
Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk KE, Mallm JP, Glauche I, Galle J, Mulaw MA, Geiger H. Hageb A, et al. Among authors: sacma m. Life Sci Alliance. 2022 Apr 29;5(8):e202201408. doi: 10.26508/lsa.202201408. Print 2022 Aug. Life Sci Alliance. 2022. PMID: 35487692 Free PMC article.
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC. Saçma M, et al. Nat Cell Biol. 2019 Nov;21(11):1309-1320. doi: 10.1038/s41556-019-0418-y. Epub 2019 Nov 4. Nat Cell Biol. 2019. PMID: 31685996
Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis.
Zioni N, Bercovich AA, Chapal-Ilani N, Bacharach T, Rappoport N, Solomon A, Avraham R, Kopitman E, Porat Z, Sacma M, Hartmut G, Scheller M, Muller-Tidow C, Lipka D, Shlush E, Minden M, Kaushansky N, Shlush LI. Zioni N, et al. Among authors: sacma m. Nat Commun. 2023 Apr 12;14(1):2070. doi: 10.1038/s41467-023-36906-1. Nat Commun. 2023. PMID: 37045808 Free PMC article.
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