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The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.
Paul A, Garcia YA, Zierer B, Patwardhan C, Gutierrez O, Hildenbrand Z, Harris DC, Balsiger HA, Sivils JC, Johnson JL, Buchner J, Chadli A, Cox MB. Paul A, et al. J Biol Chem. 2014 May 30;289(22):15297-308. doi: 10.1074/jbc.M113.535229. Epub 2014 Apr 21. J Biol Chem. 2014. PMID: 24753260 Free PMC article.
FKBP51 and FKBP52 in signaling and disease.
Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB. Storer CL, et al. Trends Endocrinol Metab. 2011 Dec;22(12):481-90. doi: 10.1016/j.tem.2011.08.001. Epub 2011 Aug 31. Trends Endocrinol Metab. 2011. PMID: 21889356 Free PMC article. Review.
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. De Leon JT, et al. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11878-83. doi: 10.1073/pnas.1105160108. Epub 2011 Jul 5. Proc Natl Acad Sci U S A. 2011. PMID: 21730179 Free PMC article.