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New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study.
Cadoni E, Magalhães PR, Emídio RM, Mendes E, Vítor J, Carvalho J, Cruz C, Victor BL, Paulo A. Cadoni E, et al. Pharmaceuticals (Basel). 2021 Jul 13;14(7):669. doi: 10.3390/ph14070669. Pharmaceuticals (Basel). 2021. PMID: 34358095 Free PMC article.
G-quadruplex (G4)-interactive small molecules have a wide range of potential applications, not only as drugs, but also as sensors of quadruplex structures. The purpose of this work is the synthesis of analogues of the bis-methylquinolinium-pyridine-2,6-dicarboxamide G4 lig …
G-quadruplex (G4)-interactive small molecules have a wide range of potential applications, not only as drugs, but also as sensors of quadrup …
Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design.
Guedes RA, Aniceto N, Andrade MAP, Salvador JAR, Guedes RC. Guedes RA, et al. Int J Mol Sci. 2019 Oct 25;20(21):5326. doi: 10.3390/ijms20215326. Int J Mol Sci. 2019. PMID: 31731563 Free PMC article.
Drug discovery now faces a new challenge, where the availability of experimental data is no longer the limiting step, and instead, making sense of the data has gained a new level of importance, propelled by the extensive incorporation of cheminformatics and bioinformatics methodo …
Drug discovery now faces a new challenge, where the availability of experimental data is no longer the limiting step, and instead, making se …