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Page 1
Genetic analysis and multimodal imaging identify novel mtDNA 12148T>C leading to multisystem dysfunction with tissue-specific heteroplasmy.
Belle K, Kreymerman A, Vadgama N, Ji MH, Randhawa S, Caicedo J, Wong M, Muscat SP, Gifford CA, Lee RT, Nasir J, Young JL, Enns G, Karakikes I, Mercola M, Wood EH. Belle K, et al. medRxiv [Preprint]. 2023 Nov 5:2023.11.03.23297854. doi: 10.1101/2023.11.03.23297854. medRxiv. 2023. PMID: 37961166 Free PMC article. Preprint.
A deep learning platform to assess drug proarrhythmia risk.
Serrano R, Feyen DAM, Bruyneel AAN, Hnatiuk AP, Vu MM, Amatya PL, Perea-Gil I, Prado M, Seeger T, Wu JC, Karakikes I, Mercola M. Serrano R, et al. Cell Stem Cell. 2023 Jan 5;30(1):86-95.e4. doi: 10.1016/j.stem.2022.12.002. Epub 2022 Dec 22. Cell Stem Cell. 2023. PMID: 36563695 Free PMC article.
Reengineering Ponatinib to Minimize Cardiovascular Toxicity.
Hnatiuk AP, Bruyneel AAN, Tailor D, Pandrala M, Dheeraj A, Li W, Serrano R, Feyen DAM, Vu MM, Amatya P, Gupta S, Nakauchi Y, Morgado I, Wiebking V, Liao R, Porteus MH, Majeti R, Malhotra SV, Mercola M. Hnatiuk AP, et al. Cancer Res. 2022 Aug 3;82(15):2777-2791. doi: 10.1158/0008-5472.CAN-21-3652. Cancer Res. 2022. PMID: 35763671 Free PMC article.
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, Kaur B, Feyen DAM, Diecke S, Snyder MP, Metallo CM, Mercola M, Karakikes I. Perea-Gil I, et al. Eur Heart J. 2022 Sep 21;43(36):3477-3489. doi: 10.1093/eurheartj/ehac305. Eur Heart J. 2022. PMID: 35728000 Free PMC article.
Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.
Feyen DAM, Perea-Gil I, Maas RGC, Harakalova M, Gavidia AA, Arthur Ataam J, Wu TH, Vink A, Pei J, Vadgama N, Suurmeijer AJ, Te Rijdt WP, Vu M, Amatya PL, Prado M, Zhang Y, Dunkenberger L, Sluijter JPG, Sallam K, Asselbergs FW, Mercola M, Karakikes I. Feyen DAM, et al. Circulation. 2021 Aug 3;144(5):382-392. doi: 10.1161/CIRCULATIONAHA.120.049844. Epub 2021 Apr 30. Circulation. 2021. PMID: 33928785 Free PMC article.