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Mitochondrial Transplantation promotes protective effector and memory CD4+ T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4+ T cells.
Headley CA, Gautam S, Olmo-Fontanez A, Garcia-Vilanova A, Dwivedi V, Schami A, Weintraub S, Tsao PS, Torrelles JB, Turner J. Headley CA, et al. bioRxiv [Preprint]. 2024 Jan 27:2024.01.24.577036. doi: 10.1101/2024.01.24.577036. bioRxiv. 2024. PMID: 38328206 Free PMC article. Preprint.
Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells.
Olmo-Fontánez AM, Scordo JM, Schami A, Garcia-Vilanova A, Pino PA, Hicks A, Mishra R, Jose Maselli D, Peters JI, Restrepo BI, Nargan K, Naidoo T, Clemens DL, Steyn AJC, Thacker VV, Turner J, Schlesinger LS, Torrelles JB. Olmo-Fontánez AM, et al. Mucosal Immunol. 2024 Apr;17(2):155-168. doi: 10.1016/j.mucimm.2024.01.001. Epub 2024 Jan 6. Mucosal Immunol. 2024. PMID: 38185331 Free PMC article.
Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging.
Headley CA, Gautam S, Olmo-Fontanez A, Garcia-Vilanova A, Dwivedi V, Akhter A, Schami A, Chiem K, Ault R, Zhang H, Cai H, Whigham A, Delgado J, Hicks A, Tsao PS, Gelfond J, Martinez-Sobrido L, Wang Y, Torrelles JB, Turner J. Headley CA, et al. Adv Sci (Weinh). 2024 Feb;11(5):e2303664. doi: 10.1002/advs.202303664. Epub 2023 Nov 21. Adv Sci (Weinh). 2024. PMID: 37990641 Free PMC article.
A new tractable method for generating human alveolar macrophage-like cells in vitro to study lung inflammatory processes and diseases.
Pahari S, Arnett E, Simper J, Azad A, Guerrero-Arguero I, Ye C, Zhang H, Cai H, Wang Y, Lai Z, Jarvis N, Lumbreras M, Maselli DJ, Peters J, Torrelles JB, Martinez-Sobrido L, Schlesinger LS. Pahari S, et al. mBio. 2023 Aug 31;14(4):e0083423. doi: 10.1128/mbio.00834-23. Epub 2023 Jun 8. mBio. 2023. PMID: 37288969 Free PMC article.
A new tractable method for generating Human Alveolar Macrophage Like cells in vitro to study lung inflammatory processes and diseases.
Pahari S, Arnett E, Simper J, Azad A, Guerrero-Arguero I, Ye C, Zhang H, Cai H, Wang Y, Lai Z, Jarvis N, Lumbreras M, Maselli-Caceres DJ, Peters J, Torrelles JB, Martinez-Sobrido L, Schlesinger LS. Pahari S, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535806. doi: 10.1101/2023.04.05.535806. bioRxiv. 2023. PMID: 37066199 Free PMC article. Updated. Preprint.
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model.
Sharan R, Ganatra SR, Bucsan AN, Cole J, Singh DK, Alvarez X, Gough M, Alvarez C, Blakley A, Ferdin J, Thippeshappa R, Singh B, Escobedo R, Shivanna V, Dick EJ Jr, Hall-Ursone S, Khader SA, Mehra S, Rengarajan J, Kaushal D. Sharan R, et al. J Clin Invest. 2022 Feb 1;132(3):e153090. doi: 10.1172/JCI153090. J Clin Invest. 2022. PMID: 34855621 Free PMC article.