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Page 1
Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition.
Chapman NS, Zhao H, Kose N, Westover JB, Kalveram B, Bombardi R, Rodriguez J, Sutton R, Genualdi J, LaBeaud AD, Mutuku FM, Pittman PR, Freiberg AN, Gowen BB, Fremont DH, Crowe JE Jr. Chapman NS, et al. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2025642118. doi: 10.1073/pnas.2025642118. Proc Natl Acad Sci U S A. 2021. PMID: 33782133 Free PMC article.
Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.
Williamson LE, Gilliland T Jr, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, Ohi MD, Klimstra WB, Crowe JE Jr. Williamson LE, et al. Cell. 2020 Dec 23;183(7):1884-1900.e23. doi: 10.1016/j.cell.2020.11.011. Epub 2020 Dec 9. Cell. 2020. PMID: 33301709 Free PMC article.
Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions.
Bozhanova NG, Sangha AK, Sevy AM, Gilchuk P, Huang K, Nargi RS, Reidy JX, Trivette A, Carnahan RH, Bukreyev A, Crowe JE Jr, Meiler J. Bozhanova NG, et al. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31142-31148. doi: 10.1073/pnas.1922654117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229516 Free PMC article.
Erratum for Research Article "Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease," by Matthew R. Vogt, Jianing Fu, Nurgun Kose, Lauren E. Williamson, Robin Bombardi, Ian Setliff, Ivelin S. Georgiev, Thomas Klose, Michael G. Rossmann, Yury A. Bochkov, James E. Gern, Richard J. Kuhn, James E. Crowe Jr.
Vogt MR, Fu J, Kose N, Williamson LE, Bombardi R, Setliff I, Georgiev IS, Klose T, Rossmann MG, Hurst BL, Tarbet EB, Bochkov YA, Gern JE, Kuhn RJ, Crowe JE Jr. Vogt MR, et al. Sci Immunol. 2020 Sep 18;5(51):eabe5512. doi: 10.1126/sciimmunol.abe5512. Sci Immunol. 2020. PMID: 32948673 Free PMC article. No abstract available.
Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics.
Gilchuk P, Bombardi RG, Erasmus JH, Tan Q, Nargi R, Soto C, Abbink P, Suscovich TJ, Durnell LA, Khandhar A, Archer J, Liang J, Fouch ME, Davidson E, Doranz BJ, Jones T, Larson E, Ertel S, Granger B, Fuerte-Stone J, Roy V, Broge T, Linnekin TC, Linde CH, Gorman MJ, Nkolola J, Alter G, Reed SG, Barouch DH, Diamond MS, Crowe JE Jr, Van Hoeven N, Thackray LB, Carnahan RH. Gilchuk P, et al. Nat Biomed Eng. 2020 Nov;4(11):1030-1043. doi: 10.1038/s41551-020-0594-x. Epub 2020 Aug 3. Nat Biomed Eng. 2020. PMID: 32747832 Free PMC article.
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE Jr. Gilchuk P, et al. Immunity. 2020 Feb 18;52(2):388-403.e12. doi: 10.1016/j.immuni.2020.01.001. Epub 2020 Feb 4. Immunity. 2020. PMID: 32023489 Free PMC article.
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE Jr. Gilchuk P, et al. Immunity. 2018 Aug 21;49(2):363-374.e10. doi: 10.1016/j.immuni.2018.06.018. Epub 2018 Jul 17. Immunity. 2018. PMID: 30029854 Free PMC article.