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Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L. Dyck L, et al. J Exp Med. 2022 Mar 7;219(3):e20210042. doi: 10.1084/jem.20210042. Epub 2022 Feb 1. J Exp Med. 2022. PMID: 35103755 Free PMC article.
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.
Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Fiala GJ, Agudelo LZ, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville H, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B, Pennington DJ, Lynch L. Lopes N, et al. Nat Immunol. 2021 Feb;22(2):179-192. doi: 10.1038/s41590-020-00848-3. Epub 2021 Jan 18. Nat Immunol. 2021. PMID: 33462452 Free PMC article.
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Hall JA, et al. Cell Metab. 2020 Oct 6;32(4):665-675.e6. doi: 10.1016/j.cmet.2020.08.016. Epub 2020 Sep 16. Cell Metab. 2020. PMID: 32941798 Free PMC article.