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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J. Green AC, et al. Among authors: sorensen cs. Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3. Nat Metab. 2023. PMID: 37012496 Free PMC article.
The histone methyltransferase SET8 is required for S-phase progression.
Jørgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sørensen CS. Jørgensen S, et al. Among authors: sorensen cs. J Cell Biol. 2007 Dec 31;179(7):1337-45. doi: 10.1083/jcb.200706150. J Cell Biol. 2007. PMID: 18166648 Free PMC article.
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity.
Köpper F, Bierwirth C, Schön M, Kunze M, Elvers I, Kranz D, Saini P, Menon MB, Walter D, Sørensen CS, Gaestel M, Helleday T, Schön MP, Dobbelstein M. Köpper F, et al. Among authors: sorensen cs. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16856-61. doi: 10.1073/pnas.1304355110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082115 Free PMC article.
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.
Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG. Galanos P, et al. Among authors: sorensen cs. Nat Cell Biol. 2016 Jul;18(7):777-89. doi: 10.1038/ncb3378. Epub 2016 Jun 20. Nat Cell Biol. 2016. PMID: 27323328 Free PMC article.
79 results