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Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma.
Jacob M, Wiedemann S, Brücher D, Pieper NM, Birkhold M, Särchen V, Jeroch J, Demes MC, Gretser S, Braun Y, Gradhand E, Rothweiler F, Michaelis M, Cinatl J Jr, Vogler M. Jacob M, et al. Among authors: sarchen v. Br J Cancer. 2023 Nov;129(10):1667-1678. doi: 10.1038/s41416-023-02430-8. Epub 2023 Sep 19. Br J Cancer. 2023. PMID: 37723317 Free PMC article.
Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy.
Särchen V, Shanmugalingam S, Kehr S, Reindl LM, Greze V, Wiedemann S, Boedicker C, Jacob M, Bankov K, Becker N, Wehner S, Theilen TM, Gretser S, Gradhand E, Kummerow C, Ullrich E, Vogler M. Särchen V, et al. Cell Death Discov. 2022 Jan 10;8(1):11. doi: 10.1038/s41420-021-00812-6. Cell Death Discov. 2022. PMID: 35013156 Free PMC article.
Unleashing the power of NK cells in anticancer immunotherapy.
Vogler M, Shanmugalingam S, Särchen V, Reindl LM, Grèze V, Buchinger L, Kühn M, Ullrich E. Vogler M, et al. Among authors: sarchen v. J Mol Med (Berl). 2022 Mar;100(3):337-349. doi: 10.1007/s00109-021-02120-z. Epub 2021 Aug 9. J Mol Med (Berl). 2022. PMID: 34374809 Free PMC article. Review.
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Heck AL, Mishra S, Prenzel T, Feulner L, Achhammer E, Särchen V, Blagg BSJ, Schneider-Brachert W, Schütze S, Fritsch J. Heck AL, et al. Among authors: sarchen v. Immunobiology. 2021 Mar;226(2):152070. doi: 10.1016/j.imbio.2021.152070. Epub 2021 Feb 5. Immunobiology. 2021. PMID: 33639524 Free article.
Palmitoylation is required for TNF-R1 signaling.
Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J. Zingler P, et al. Among authors: sarchen v. Cell Commun Signal. 2019 Aug 5;17(1):90. doi: 10.1186/s12964-019-0405-8. Cell Commun Signal. 2019. PMID: 31382980 Free PMC article.
12 results