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CRISPR-Analytics (CRISPR-A): A platform for precise analytics and simulations for gene editing.
Sanvicente-García M, García-Valiente A, Jouide S, Jaraba-Wallace J, Bautista E, Escobosa M, Sánchez-Mejías A, Güell M. Sanvicente-García M, et al. Among authors: sanchez mejias a. PLoS Comput Biol. 2023 May 30;19(5):e1011137. doi: 10.1371/journal.pcbi.1011137. eCollection 2023 May. PLoS Comput Biol. 2023. PMID: 37253059 Free PMC article.
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins.
Alonso-Lerma B, Jabalera Y, Samperio S, Morin M, Fernandez A, Hille LT, Silverstein RA, Quesada-Ganuza A, Reifs A, Fernández-Peñalver S, Benitez Y, Soletto L, Gavira JA, Diaz A, Vranken W, Sanchez-Mejias A, Güell M, Mojica FJM, Kleinstiver BP, Moreno-Pelayo MA, Montoliu L, Perez-Jimenez R. Alonso-Lerma B, et al. Among authors: sanchez mejias a. Nat Microbiol. 2023 Jan;8(1):77-90. doi: 10.1038/s41564-022-01265-y. Epub 2023 Jan 2. Nat Microbiol. 2023. PMID: 36593295 Free PMC article.
Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.
Swiderska-Syn M, Mir-Pedrol J, Oles A, Schleuger O, Salvador AD, Greiner SM, Seward C, Yang F, Babcock BR, Shen C, Wynn DT, Sanchez-Mejias A, Gershon TR, Martin V, McCrea HJ, Lindsey KG, Krieg C, Rodriguez-Blanco J. Swiderska-Syn M, et al. Among authors: sanchez mejias a. Sci Adv. 2022 Jul 22;8(29):eabj9138. doi: 10.1126/sciadv.abj9138. Epub 2022 Jul 20. Sci Adv. 2022. PMID: 35857834 Free PMC article.
Pan-cancer pervasive upregulation of 3' UTR splicing drives tumourigenesis.
Chan JJ, Zhang B, Chew XH, Salhi A, Kwok ZH, Lim CY, Desi N, Subramaniam N, Siemens A, Kinanti T, Ong S, Sanchez-Mejias A, Ly PT, An O, Sundar R, Fan X, Wang S, Siew BE, Lee KC, Chong CS, Lieske B, Cheong WK, Goh Y, Fam WN, Ooi MG, Koh BTH, Iyer SG, Ling WH, Chen J, Yoong BK, Chanwat R, Bonney GK, Goh BKP, Zhai W, Fullwood MJ, Wang W, Tan KK, Chng WJ, Dan YY, Pitt JJ, Roca X, Guccione E, Vardy LA, Chen L, Gao X, Chow PKH, Yang H, Tay Y. Chan JJ, et al. Among authors: sanchez mejias a. Nat Cell Biol. 2022 Jun;24(6):928-939. doi: 10.1038/s41556-022-00913-z. Epub 2022 May 26. Nat Cell Biol. 2022. PMID: 35618746 Free PMC article.
MiR-138 is a potent regulator of the heterogenous MYC transcript population in cancers.
Desi N, Teh V, Tong QY, Lim CY, Tabatabaeian H, Chew XH, Sanchez-Mejias A, Chan JJ, Zhang B, Pitcheshwar P, Siew BE, Wang S, Lee KC, Chong CS, Cheong WK, Lieske B, Tan IJ, Tan KK, Tay Y. Desi N, et al. Among authors: sanchez mejias a. Oncogene. 2022 Feb;41(8):1178-1189. doi: 10.1038/s41388-021-02084-x. Epub 2021 Dec 22. Oncogene. 2022. PMID: 34937878 Free PMC article.
Find and cut-and-transfer (FiCAT) mammalian genome engineering.
Pallarès-Masmitjà M, Ivančić D, Mir-Pedrol J, Jaraba-Wallace J, Tagliani T, Oliva B, Rahmeh A, Sánchez-Mejías A, Güell M. Pallarès-Masmitjà M, et al. Among authors: sanchez mejias a. Nat Commun. 2021 Dec 3;12(1):7071. doi: 10.1038/s41467-021-27183-x. Nat Commun. 2021. PMID: 34862378 Free PMC article.
Cryptic Amyloidogenic Elements in the 3' UTRs of Neurofilament Genes Trigger Axonal Neuropathy.
Rebelo AP, Abrams AJ, Cottenie E, Horga A, Gonzalez M, Bis DM, Sanchez-Mejias A, Pinto M, Buglo E, Markel K, Prince J, Laura M, Houlden H, Blake J, Woodward C, Sweeney MG, Holton JL, Hanna M, Dallman JE, Auer-Grumbach M, Reilly MM, Zuchner S. Rebelo AP, et al. Among authors: sanchez mejias a. Am J Hum Genet. 2016 Apr 7;98(4):597-614. doi: 10.1016/j.ajhg.2016.02.022. Epub 2016 Mar 31. Am J Hum Genet. 2016. PMID: 27040688 Free PMC article.
24 results