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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1.
Nat Commun. 2023.
PMID: 37316487
Free PMC article.
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants.
Ryan TAJ, Preston RJS, O'Neill LAJ.
Ryan TAJ, et al.
Biochem J. 2022 Mar 31;479(6):731-750. doi: 10.1042/BCJ20210522.
Biochem J. 2022.
PMID: 35344028
Review.
Item in Clipboard
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ.
Hooftman A, et al. Among authors: ryan taj.
Nature. 2023 Mar;615(7952):490-498. doi: 10.1038/s41586-023-05720-6. Epub 2023 Mar 8.
Nature. 2023.
PMID: 36890227
Free PMC article.
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Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, O' Brien EC, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, O' Donnell JS, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ.
Ryan TAJ, et al.
Nat Commun. 2023 Jul 20;14(1):4374. doi: 10.1038/s41467-023-40034-1.
Nat Commun. 2023.
PMID: 37474527
Free PMC article.
No abstract available.
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Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities.
Ryan TAJ, O'Neill LAJ.
Ryan TAJ, et al.
Eur J Immunol. 2022 Jul;52(7):1024-1034. doi: 10.1002/eji.202149410. Epub 2022 May 24.
Eur J Immunol. 2022.
PMID: 35569038
Free PMC article.
Review.
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An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation.
Ryan TAJ, O'Neill LAJ.
Ryan TAJ, et al.
Cells. 2023 Feb 28;12(5):778. doi: 10.3390/cells12050778.
Cells. 2023.
PMID: 36899914
Free PMC article.
Review.
Item in Clipboard
Modification of Proteins by Metabolites in Immunity.
Diskin C, Ryan TAJ, O'Neill LAJ.
Diskin C, et al. Among authors: ryan taj.
Immunity. 2021 Jan 12;54(1):19-31. doi: 10.1016/j.immuni.2020.09.014. Epub 2020 Nov 20.
Immunity. 2021.
PMID: 33220233
Free article.
Review.
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The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils.
Toller-Kawahisa JE, Hiroki CH, Silva CMS, Nascimento DC, Públio GA, Martins TV, Damasceno LEA, Veras FP, Viacava PR, Sukesada FY, Day EA, Zotta A, Ryan TAJ, Moreira da Silva R, Cunha TM, Lopes NP, Cunha FQ, O'Neill LAJ, Alves-Filho JC.
Toller-Kawahisa JE, et al. Among authors: ryan taj.
Nat Commun. 2023 Jul 17;14(1):4280. doi: 10.1038/s41467-023-40021-6.
Nat Commun. 2023.
PMID: 37460614
Free PMC article.
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