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Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase is structurally, functionally and phylogenetically distinct from its N-acetyltransferase (NAT) homologues.
Karagianni EP, Kontomina E, Lowe ED, Athanasopoulos K, Papanikolaou G, Garefalaki V, Kotseli V, Zaliou S, Grimaud T, Arvaniti K, Tsatiri MA, Fakis G, Glenn AE, Roversi P, Abuhammad A, Ryan A, Sim RB, Sim E, Boukouvala S. Karagianni EP, et al. Among authors: ryan a. FEBS J. 2023 May;290(9):2412-2436. doi: 10.1111/febs.16642. Epub 2022 Oct 18. FEBS J. 2023. PMID: 36178468 Free article.
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide.
Wang CJ, Laurieri N, Abuhammad A, Lowe E, Westwood I, Ryan A, Sim E. Wang CJ, et al. Among authors: ryan a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):2-7. doi: 10.1107/S1744309109044741. Epub 2009 Dec 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20057057 Free PMC article.
A novel mechanism for azoreduction.
Ryan A, Laurieri N, Westwood I, Wang CJ, Lowe E, Sim E. Ryan A, et al. J Mol Biol. 2010 Jul 2;400(1):24-37. doi: 10.1016/j.jmb.2010.04.023. Epub 2010 Apr 24. J Mol Biol. 2010. PMID: 20417637
3,082 results