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Page 1
Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease.
Jansen PA, van Diepen JA, Ritzen B, Zeeuwen PL, Cacciatore I, Cornacchia C, van Vlijmen-Willems IM, de Heuvel E, Botman PN, Blaauw RH, Hermkens PH, Rutjes FP, Schalkwijk J. Jansen PA, et al. Among authors: rutjes fp. ACS Chem Biol. 2013 Mar 15;8(3):530-4. doi: 10.1021/cb3006424. Epub 2013 Jan 2. ACS Chem Biol. 2013. PMID: 23270378
PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.
van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Hooiveld GJ, Rommelaere S, Galland F, Naquet P, Rutjes FP, Mensink RP, Schrauwen P, Tack CJ, Netea MG, Kersten S, Schalkwijk J, Stienstra R. van Diepen JA, et al. Among authors: rutjes fp. J Hepatol. 2014 Aug;61(2):366-72. doi: 10.1016/j.jhep.2014.04.013. Epub 2014 Apr 18. J Hepatol. 2014. PMID: 24751833
Novel pantothenate derivatives for anti-malarial chemotherapy.
Pett HE, Jansen PA, Hermkens PH, Botman PN, Beuckens-Schortinghuis CA, Blaauw RH, Graumans W, van de Vegte-Bolmer M, Koolen KM, Rutjes FP, Dechering KJ, Sauerwein RW, Schalkwijk J. Pett HE, et al. Among authors: rutjes fp. Malar J. 2015 Apr 18;14:169. doi: 10.1186/s12936-015-0673-8. Malar J. 2015. PMID: 25927675 Free PMC article.
Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria.
Jansen PAM, van der Krieken DA, Botman PNM, Blaauw RH, Cavina L, Raaijmakers EM, de Heuvel E, Sandrock J, Pennings LJ, Hermkens PHH, Zeeuwen PLJM, Rutjes FPJT, Schalkwijk J. Jansen PAM, et al. J Antibiot (Tokyo). 2019 Sep;72(9):682-692. doi: 10.1038/s41429-019-0196-6. Epub 2019 Jun 6. J Antibiot (Tokyo). 2019. PMID: 31171848 Free PMC article.
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.
Schalkwijk J, Allman EL, Jansen PAM, de Vries LE, Verhoef JMJ, Jackowski S, Botman PNM, Beuckens-Schortinghuis CA, Koolen KMJ, Bolscher JM, Vos MW, Miller K, Reeves SA, Pett H, Trevitt G, Wittlin S, Scheurer C, Sax S, Fischli C, Angulo-Barturen I, Jiménez-Diaz MB, Josling G, Kooij TWA, Bonnert R, Campo B, Blaauw RH, Rutjes FPJT, Sauerwein RW, Llinás M, Hermkens PHH, Dechering KJ. Schalkwijk J, et al. Sci Transl Med. 2019 Sep 18;11(510):eaas9917. doi: 10.1126/scitranslmed.aas9917. Sci Transl Med. 2019. PMID: 31534021
Bioconjugation: How to pick a single amine?
Rutjes FP. Rutjes FP. Nat Chem Biol. 2015 May;11(5):306-7. doi: 10.1038/nchembio.1791. Epub 2015 Mar 30. Nat Chem Biol. 2015. PMID: 25822916 No abstract available.
189 results