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Decrypting drug actions and protein modifications by dose- and time-resolved proteomics.
Zecha J, Bayer FP, Wiechmann S, Woortman J, Berner N, Müller J, Schneider A, Kramer K, Abril-Gil M, Hopf T, Reichart L, Chen L, Hansen FM, Lechner S, Samaras P, Eckert S, Lautenbacher L, Reinecke M, Hamood F, Prokofeva P, Vornholz L, Falcomatà C, Dorsch M, Schröder A, Venhuizen A, Wilhelm S, Médard G, Stoehr G, Ruland J, Grüner BM, Saur D, Buchner M, Ruprecht B, Hahne H, The M, Wilhelm M, Kuster B. Zecha J, et al. Among authors: ruprecht b. Science. 2023 Apr 7;380(6640):93-101. doi: 10.1126/science.ade3925. Epub 2023 Mar 16. Science. 2023. PMID: 36926954 Free PMC article.
The target landscape of clinical kinase drugs.
Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B. Klaeger S, et al. Among authors: ruprecht b. Science. 2017 Dec 1;358(6367):eaan4368. doi: 10.1126/science.aan4368. Science. 2017. PMID: 29191878 Free PMC article.
Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors.
Reinecke M, Ruprecht B, Poser S, Wiechmann S, Wilhelm M, Heinzlmeir S, Kuster B, Médard G. Reinecke M, et al. Among authors: ruprecht b. ACS Chem Biol. 2019 Apr 19;14(4):655-664. doi: 10.1021/acschembio.8b01020. Epub 2019 Apr 3. ACS Chem Biol. 2019. PMID: 30901187
Proteome activity landscapes of tumor cell lines determine drug responses.
Frejno M, Meng C, Ruprecht B, Oellerich T, Scheich S, Kleigrewe K, Drecoll E, Samaras P, Hogrebe A, Helm D, Mergner J, Zecha J, Heinzlmeir S, Wilhelm M, Dorn J, Kvasnicka HM, Serve H, Weichert W, Kuster B. Frejno M, et al. Among authors: ruprecht b. Nat Commun. 2020 Jul 20;11(1):3639. doi: 10.1038/s41467-020-17336-9. Nat Commun. 2020. PMID: 32686665 Free PMC article.
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
Heinzlmeir S, Kudlinzki D, Sreeramulu S, Klaeger S, Gande SL, Linhard V, Wilhelm M, Qiao H, Helm D, Ruprecht B, Saxena K, Médard G, Schwalbe H, Kuster B. Heinzlmeir S, et al. Among authors: ruprecht b. ACS Chem Biol. 2016 Dec 16;11(12):3400-3411. doi: 10.1021/acschembio.6b00709. Epub 2016 Nov 7. ACS Chem Biol. 2016. PMID: 27768280
Optimized chemical proteomics assay for kinase inhibitor profiling.
Médard G, Pachl F, Ruprecht B, Klaeger S, Heinzlmeir S, Helm D, Qiao H, Ku X, Wilhelm M, Kuehne T, Wu Z, Dittmann A, Hopf C, Kramer K, Kuster B. Médard G, et al. Among authors: ruprecht b. J Proteome Res. 2015 Mar 6;14(3):1574-86. doi: 10.1021/pr5012608. Epub 2015 Feb 20. J Proteome Res. 2015. PMID: 25660469
49 results