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Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue.
Ruppert PMM, Michielsen CCJR, Hazebroek EJ, Pirayesh A, Olivecrona G, Afman LA, Kersten S. Ruppert PMM, et al. Mol Metab. 2020 Oct;40:101033. doi: 10.1016/j.molmet.2020.101033. Epub 2020 Jun 3. Mol Metab. 2020. PMID: 32504883 Free PMC article. Clinical Trial.
A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.
Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, Kooijman S, Guigas B, Houtkooper RH, Rensen PCN, Boon MR. Kuipers EN, et al. Among authors: ruppert pmm. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E820-E830. doi: 10.1152/ajpendo.00123.2019. Epub 2019 Aug 6. Am J Physiol Endocrinol Metab. 2019. PMID: 31386566 Free article.
A lipase fusion feasts on fat.
Ruppert PMM, Kersten S. Ruppert PMM, et al. J Biol Chem. 2020 Mar 6;295(10):2913-2914. doi: 10.1074/jbc.H120.012744. J Biol Chem. 2020. PMID: 32144145 Free PMC article.
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Khani S, et al. Among authors: ruppert pmm. Nat Metab. 2024 Apr 29. doi: 10.1038/s42255-024-01033-8. Online ahead of print. Nat Metab. 2024. PMID: 38684889