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TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2.
Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE. Woolums BM, et al. Among authors: ruppell kt. Nat Commun. 2020 May 29;11(1):2679. doi: 10.1038/s41467-020-16411-5. Nat Commun. 2020. PMID: 32471994 Free PMC article.
Gliotransmission and adenosine signaling promote axon regeneration.
Wang F, Ruppell KT, Zhou S, Qu Y, Gong J, Shang Y, Wu J, Liu X, Diao W, Li Y, Xiang Y. Wang F, et al. Among authors: ruppell kt. Dev Cell. 2023 Apr 24;58(8):660-676.e7. doi: 10.1016/j.devcel.2023.03.007. Epub 2023 Apr 6. Dev Cell. 2023. PMID: 37028426 Free PMC article.