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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Felszeghy S, et al. Among authors: ruotsalainen ak. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14. Redox Biol. 2019. PMID: 30253279 Free PMC article.
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. Leinonen HM, et al. Among authors: ruotsalainen ak. Cancer Res. 2012 Dec 1;72(23):6227-35. doi: 10.1158/0008-5472.CAN-12-1166. Epub 2012 Oct 4. Cancer Res. 2012. PMID: 23041549
The absence of macrophage Nrf2 promotes early atherogenesis.
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. Ruotsalainen AK, et al. Cardiovasc Res. 2013 Apr 1;98(1):107-15. doi: 10.1093/cvr/cvt008. Epub 2013 Jan 22. Cardiovasc Res. 2013. PMID: 23341579
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.
Ruotsalainen AK, Lappalainen JP, Heiskanen E, Merentie M, Sihvola V, Näpänkangas J, Lottonen-Raikaslehto L, Kansanen E, Adinolfi S, Kaarniranta K, Ylä-Herttuala S, Jauhiainen M, Pirinen E, Levonen AL. Ruotsalainen AK, et al. Cardiovasc Res. 2019 Jan 1;115(1):243-254. doi: 10.1093/cvr/cvy143. Cardiovasc Res. 2019. PMID: 29917052
Characterizing valve dynamics in mice by high-resolution cine-MRI.
Weisell J, Ruotsalainen AK, Laakso H, Ylä-Herttuala E, Näpänkangas J, Levonen AL, Liimatainen T, Rysä J. Weisell J, et al. Among authors: ruotsalainen ak. NMR Biomed. 2019 Aug;32(8):e4108. doi: 10.1002/nbm.4108. Epub 2019 May 21. NMR Biomed. 2019. PMID: 31112347
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight From Mouse Models.
Cedó L, Metso J, Santos D, García-León A, Plana N, Sabate-Soler S, Rotllan N, Rivas-Urbina A, Méndez-Lara KA, Tondo M, Girona J, Julve J, Pallarès V, Benitez-Amaro A, Llorente-Cortes V, Pérez A, Gómez-Coronado D, Ruotsalainen AK, Levonen AL, Sanchez-Quesada JL, Masana L, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC. Cedó L, et al. Among authors: ruotsalainen ak. Circ Res. 2020 Aug 28;127(6):778-792. doi: 10.1161/CIRCRESAHA.119.316424. Epub 2020 Jun 4. Circ Res. 2020. PMID: 32495699
Nucleic Acid-Based Therapies for Atherosclerosis.
Mäkinen P, Ruotsalainen AK, Ylä-Herttuala S. Mäkinen P, et al. Among authors: ruotsalainen ak. Curr Atheroscler Rep. 2020 Feb 7;22(2):10. doi: 10.1007/s11883-020-0826-2. Curr Atheroscler Rep. 2020. PMID: 32034521 Free PMC article. Review.
16 results