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Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility.
Velasco I, Franssen D, Daza-Dueñas S, Skrapits K, Takács S, Torres E, Rodríguez-Vazquez E, Ruiz-Cruz M, León S, Kukoricza K, Zhang FP, Ruohonen S, Luque-Cordoba D, Priego-Capote F, Gaytan F, Ruiz-Pino F, Hrabovszky E, Poutanen M, Vázquez MJ, Tena-Sempere M. Velasco I, et al. Among authors: ruohonen s. Metabolism. 2023 Jul;144:155556. doi: 10.1016/j.metabol.2023.155556. Epub 2023 Apr 29. Metabolism. 2023. PMID: 37121307 Free article.
Hydroxysteroid (17β) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice.
Adam M, Heikelä H, Sobolewski C, Portius D, Mäki-Jouppila J, Mehmood A, Adhikari P, Esposito I, Elo LL, Zhang FP, Ruohonen ST, Strauss L, Foti M, Poutanen M. Adam M, et al. FASEB J. 2018 Jun;32(6):3434-3447. doi: 10.1096/fj.201700914R. Epub 2018 Jan 31. FASEB J. 2018. PMID: 29401633
., Mehmood, A., Adhikari, P., Esposito, I., Elo, L. L., Zhang, F.-P., Ruohonen, S. T., Strauss, L., Foti, M., Poutanen, M. Hydroxysteroid (17beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice....
., Mehmood, A., Adhikari, P., Esposito, I., Elo, L. L., Zhang, F.-P., Ruohonen, S. T., Strauss, L., Foti, M., Poutanen, M. Hyd …
Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis.
Velasco I, León S, Barroso A, Ruiz-Pino F, Heras V, Torres E, León M, Ruohonen ST, García-Galiano D, Romero-Ruiz A, Sánchez-Garrido MA, Ohlsson C, Castellano JM, Roa J, Poutanen M, Pinilla L, Vázquez MJ, Tena-Sempere M. Velasco I, et al. Among authors: ruohonen st. Metabolism. 2019 Sep;98:84-94. doi: 10.1016/j.metabol.2019.06.007. Epub 2019 Jun 19. Metabolism. 2019. PMID: 31226351
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice.
Heikelä H, Ruohonen ST, Adam M, Viitanen R, Liljenbäck H, Eskola O, Gabriel M, Mairinoja L, Pessia A, Velagapudi V, Roivainen A, Zhang FP, Strauss L, Poutanen M. Heikelä H, et al. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E494-E508. doi: 10.1152/ajpendo.00042.2020. Epub 2020 Jul 21. Am J Physiol Endocrinol Metab. 2020. PMID: 32691632 Free article.
Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice.
Patyra K, Jaeschke H, Löf C, Jännäri M, Ruohonen ST, Undeutsch H, Khalil M, Kero A, Poutanen M, Toppari J, Chen M, Weinstein LS, Paschke R, Kero J. Patyra K, et al. Among authors: ruohonen st. FASEB J. 2018 May 25:fj201800211R. doi: 10.1096/fj.201800211R. Online ahead of print. FASEB J. 2018. PMID: 29799790
Here, we demonstrate that the thyrocyte-specific deletion of G(s)-protein alpha subunit (Galpha(s)) in adult mice [tamoxifen-inducible G(s) protein alpha subunit deficient (iTGalpha(s)KO) mice] rapidly impairs thyrocyte function and leads to hypothyroi …
Here, we demonstrate that the thyrocyte-specific deletion of G(s)-protein alpha subunit (Galpha(s)) in adult mice [tamoxifen-i …
78 results