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Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Runfola M, Perni M, Yang X, Marchese M, Bacci A, Mero S, Santorelli FM, Polini B, Chiellini G, Giuliani D, Vilella A, Bodria M, Daini E, Vandini E, Rudge S, Gul S, Wakelam MOJ, Vendruscolo M, Rapposelli S. Runfola M, et al. Pharmaceuticals (Basel). 2021 Dec 19;14(12):1330. doi: 10.3390/ph14121330. Pharmaceuticals (Basel). 2021. PMID: 34959730 Free PMC article.
Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.
Chiellini G, Nesi G, Sestito S, Chiarugi S, Runfola M, Espinoza S, Sabatini M, Bellusci L, Laurino A, Cichero E, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S. Chiellini G, et al. Among authors: runfola m. J Med Chem. 2016 Nov 10;59(21):9825-9836. doi: 10.1021/acs.jmedchem.6b01092. Epub 2016 Oct 21. J Med Chem. 2016. PMID: 27731647
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics.
Runfola M, Sestito S, Gul S, Chiellini G, Rapposelli S. Runfola M, et al. Data Brief. 2020 Jan 31;29:105206. doi: 10.1016/j.dib.2020.105206. eCollection 2020 Apr. Data Brief. 2020. PMID: 32071982 Free PMC article.
The data reported herein support our research article entitled "Design, synthesis and biological evaluation of novel TRbeta selective agonists sustained by ADME-Toxicity analysis" by Runfola M., Sestito S., et al. [1]....
The data reported herein support our research article entitled "Design, synthesis and biological evaluation of novel TRbeta selective agonis …
Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6.
Bellusci L, Runfola M, Carnicelli V, Sestito S, Fulceri F, Santucci F, Lenzi P, Fornai F, Rapposelli S, Origlia N, Zucchi R, Chiellini G. Bellusci L, et al. Among authors: runfola m. Molecules. 2020 Feb 26;25(5):1054. doi: 10.3390/molecules25051054. Molecules. 2020. PMID: 32110992 Free PMC article.
36 results