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Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.
Rukhlenko OS, Khorsand F, Krstic A, Rozanc J, Alexopoulos LG, Rauch N, Erickson KE, Hlavacek WS, Posner RG, Gómez-Coca S, Rosta E, Fitzgibbon C, Matallanas D, Rauch J, Kolch W, Kholodenko BN. Rukhlenko OS, et al. Cell Syst. 2018 Aug 22;7(2):161-179.e14. doi: 10.1016/j.cels.2018.06.002. Epub 2018 Jul 11. Cell Syst. 2018. PMID: 30007540 Free PMC article.
Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor.
Erickson KE, Rukhlenko OS, Shahinuzzaman M, Slavkova KP, Lin YT, Suderman R, Stites EC, Anghel M, Posner RG, Barua D, Kholodenko BN, Hlavacek WS. Erickson KE, et al. Among authors: rukhlenko os. PLoS Comput Biol. 2019 Jan 17;15(1):e1006706. doi: 10.1371/journal.pcbi.1006706. eCollection 2019 Jan. PLoS Comput Biol. 2019. PMID: 30653502 Free PMC article.
Mapping connections in signaling networks with ambiguous modularity.
Lill D, Rukhlenko OS, Mc Elwee AJ, Kashdan E, Timmer J, Kholodenko BN. Lill D, et al. Among authors: rukhlenko os. NPJ Syst Biol Appl. 2019 May 23;5:19. doi: 10.1038/s41540-019-0096-1. eCollection 2019. NPJ Syst Biol Appl. 2019. PMID: 31149348 Free PMC article.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, Matallanas D, Kotlyar M, Jurisica I, Curak J, Wong V, Stagljar I, LeBihan T, Imrie L, Pillai P, Lynn MA, Fasterius E, Al-Khalili Szigyarto C, Breen J, Kiel C, Serrano L, Rauch N, Rukhlenko O, Kholodenko BN, Iglesias-Martinez LF, Ryan CJ, Pilkington R, Cammareri P, Sansom O, Shave S, Auer M, Horn N, Klose F, Ueffing M, Boldt K, Lynn DJ, Kolch W. Kennedy SA, et al. Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9. Nat Commun. 2020. PMID: 31980649 Free PMC article.
23 results