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Autophagy maintains stemness by preventing senescence.
García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, Sandri M, Muñoz-Cánoves P. García-Prat L, et al. Among authors: ruiz bonilla v. Nature. 2016 Jan 7;529(7584):37-42. doi: 10.1038/nature16187. Nature. 2016. PMID: 26738589
Geriatric muscle stem cells switch reversible quiescence into senescence.
Sousa-Victor P, Gutarra S, García-Prat L, Rodriguez-Ubreva J, Ortet L, Ruiz-Bonilla V, Jardí M, Ballestar E, González S, Serrano AL, Perdiguero E, Muñoz-Cánoves P. Sousa-Victor P, et al. Among authors: ruiz bonilla v. Nature. 2014 Feb 20;506(7488):316-21. doi: 10.1038/nature13013. Epub 2014 Feb 12. Nature. 2014. PMID: 24522534
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.
García-Prat L, Perdiguero E, Alonso-Martín S, Dell'Orso S, Ravichandran S, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Ruiz-Bonilla V, Flández M, Moiseeva V, Rebollo E, Jardí M, Sun HW, Musarò A, Sandri M, Del Sol A, Sartorelli V, Muñoz-Cánoves P. García-Prat L, et al. Among authors: ruiz bonilla v. Nat Cell Biol. 2020 Nov;22(11):1307-1318. doi: 10.1038/s41556-020-00593-7. Epub 2020 Oct 26. Nat Cell Biol. 2020. PMID: 33106654
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress.
Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Castellanos A, Welz PS, Caballero JM, Sassone-Corsi P, Muñoz-Cánoves P, Benitah SA. Solanas G, et al. Among authors: ruiz bonilla v. Cell. 2017 Aug 10;170(4):678-692.e20. doi: 10.1016/j.cell.2017.07.035. Cell. 2017. PMID: 28802040 Free article.
Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.
Vidal B, Ardite E, Suelves M, Ruiz-Bonilla V, Janué A, Flick MJ, Degen JL, Serrano AL, Muñoz-Cánoves P. Vidal B, et al. Among authors: ruiz bonilla v. Hum Mol Genet. 2012 May 1;21(9):1989-2004. doi: 10.1093/hmg/dds012. Epub 2012 Mar 1. Hum Mol Genet. 2012. PMID: 22381526 Free PMC article.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M, Zorzano A. Sebastián D, et al. Among authors: ruiz bonilla v. EMBO J. 2016 Aug 1;35(15):1677-93. doi: 10.15252/embj.201593084. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334614 Free PMC article.
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