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Page 1
CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status.
Rubio C, Martínez-Fernández M, Segovia C, Lodewijk I, Suarez-Cabrera C, Segrelles C, López-Calderón F, Munera-Maravilla E, Santos M, Bernardini A, García-Escudero R, Lorz C, Gómez-Rodriguez MJ, de Velasco G, Otero I, Villacampa F, Guerrero-Ramos F, Ruiz S, de la Rosa F, Domínguez-Rodríguez S, Real FX, Malats N, Castellano D, Dueñas M, Paramio JM. Rubio C, et al. Among authors: ruiz s. Clin Cancer Res. 2019 Jan 1;25(1):390-402. doi: 10.1158/1078-0432.CCR-18-0685. Epub 2018 Sep 21. Clin Cancer Res. 2019. PMID: 30242024
Unexpected roles for pRb in mouse skin carcinogenesis.
Ruiz S, Santos M, Lara MF, Segrelles C, Ballestín C, Paramio JM. Ruiz S, et al. Cancer Res. 2005 Nov 1;65(21):9678-86. doi: 10.1158/0008-5472.CAN-05-1853. Cancer Res. 2005. PMID: 16266987
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.
Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltrán L, Martínez-Cruz AB, García-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J. Segrelles C, et al. Among authors: ruiz s. Cancer Res. 2007 Nov 15;67(22):10879-88. doi: 10.1158/0008-5472.CAN-07-2564. Cancer Res. 2007. PMID: 18006833
p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.
Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM. Saiz-Ladera C, et al. Among authors: ruiz s. Oncogene. 2014 Sep 11;33(37):4599-4612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14. Oncogene. 2014. PMID: 24121270 Free PMC article.
p107 acts as a tumor suppressor in pRb-deficient epidermis.
Lara MF, Santos M, Ruiz S, Segrelles C, Moral M, Martínez-Cruz AB, Hernández P, Martínez-Palacio J, Lorz C, García-Escudero R, Paramio JM. Lara MF, et al. Among authors: ruiz s. Mol Carcinog. 2008 Feb;47(2):105-13. doi: 10.1002/mc.20367. Mol Carcinog. 2008. PMID: 17932945
920 results