Ruiz CH - Search Results

1

Imidazopyridines as selective CYP3A4 inhibitors.

Song X, Li X, Ruiz CH, Yin Y, Feng Y, Kamenecka TM, Cameron MD. Song X, et al. Among authors: ruiz ch. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1611-4. doi: 10.1016/j.bmcl.2011.12.125. Epub 2012 Jan 4. Bioorg Med Chem Lett. 2012. PMID: 22264486 Free PMC article.

2

Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II.

Feng Y, Cameron MD, Frackowiak B, Griffin E, Lin L, Ruiz C, Schröter T, LoGrasso P. Feng Y, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2355-60. doi: 10.1016/j.bmcl.2006.12.043. Epub 2006 Dec 21. Bioorg Med Chem Lett. 2007. PMID: 17368019

3

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

Feng Y, Yin Y, Weiser A, Griffin E, Cameron MD, Lin L, Ruiz C, Schürer SC, Inoue T, Rao PV, Schröter T, Lograsso P. Feng Y, et al. J Med Chem. 2008 Nov 13;51(21):6642-5. doi: 10.1021/jm800986w. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834107 Free PMC article.

4

Chroman-3-amides as potent Rho kinase inhibitors.

Chen YT, Bannister TD, Weiser A, Griffin E, Lin L, Ruiz C, Cameron MD, Schürer S, Duckett D, Schröter T, LoGrasso P, Feng Y. Chen YT, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6406-9. doi: 10.1016/j.bmcl.2008.10.080. Epub 2008 Oct 22. Bioorg Med Chem Lett. 2008. PMID: 18990570

5

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.

Sessions EH, Yin Y, Bannister TD, Weiser A, Griffin E, Pocas J, Cameron MD, Ruiz C, Lin L, Schürer SC, Schröter T, LoGrasso P, Feng Y. Sessions EH, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6390-3. doi: 10.1016/j.bmcl.2008.10.095. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18996009

6

Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways.

Li X, He Y, Ruiz CH, Koenig M, Cameron MD, Vojkovsky T. Li X, et al. Among authors: ruiz ch. Drug Metab Dispos. 2009 Jun;37(6):1242-50. doi: 10.1124/dmd.108.025932. Epub 2009 Mar 12. Drug Metab Dispos. 2009. PMID: 19282395 Free PMC article.

7

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.

Yin Y, Lin L, Ruiz C, Cameron MD, Pocas J, Grant W, Schröter T, Chen W, Duckett D, Schürer S, Lograsso P, Feng Y. Yin Y, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6686-90. doi: 10.1016/j.bmcl.2009.09.115. Epub 2009 Oct 3. Bioorg Med Chem Lett. 2009. PMID: 19837589

8

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J, Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV. Kamenecka T, et al. Among authors: ruiz ch. J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f. J Med Chem. 2010. PMID: 19947601 Free PMC article.

9

The development of benzimidazoles as selective rho kinase inhibitors.

Sessions EH, Smolinski M, Wang B, Frackowiak B, Chowdhury S, Yin Y, Chen YT, Ruiz C, Lin L, Pocas J, Schröter T, Cameron MD, LoGrasso P, Feng Y, Bannister TD. Sessions EH, et al. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1939-43. doi: 10.1016/j.bmcl.2010.01.124. Epub 2010 Feb 1. Bioorg Med Chem Lett. 2010. PMID: 20167489

10

Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.

Fang X, Yin Y, Chen YT, Yao L, Wang B, Cameron MD, Lin L, Khan S, Ruiz C, Schröter T, Grant W, Weiser A, Pocas J, Pachori A, Schürer S, Lograsso P, Feng Y. Fang X, et al. J Med Chem. 2010 Aug 12;53(15):5727-37. doi: 10.1021/jm100579r. J Med Chem. 2010. PMID: 20684608

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