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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.
Bujotzek A, Tiefenthaler G, Lariviere L, D'Andrea L, Marquez EA, Rudloff I, Cho SX, Deen NS, Richter W, Regenass-Lechner F, Poehler A, Whisstock JC, Sydow-Andersen J, Reiser X, Schuster S, Neubauer J, Hoepfl S, Richter K, Nold MF, Nold-Petry CA, Schumacher F, Ellisdon AM. Bujotzek A, et al. Among authors: rudloff i. Cell Chem Biol. 2022 Apr 21;29(4):586-596.e4. doi: 10.1016/j.chembiol.2021.10.004. Epub 2021 Oct 25. Cell Chem Biol. 2022. PMID: 34699747 Free article.
Remifentanil ameliorates intestinal ischemia-reperfusion injury.
Cho SS, Rudloff I, Berger PJ, Irwin MG, Nold MF, Cheng W, Nold-Petry CA. Cho SS, et al. Among authors: rudloff i. BMC Gastroenterol. 2013 Apr 22;13:69. doi: 10.1186/1471-230X-13-69. BMC Gastroenterol. 2013. PMID: 23607370 Free PMC article.
Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia.
Nold MF, Mangan NE, Rudloff I, Cho SX, Shariatian N, Samarasinghe TD, Skuza EM, Pedersen J, Veldman A, Berger PJ, Nold-Petry CA. Nold MF, et al. Among authors: rudloff i. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14384-9. doi: 10.1073/pnas.1306859110. Epub 2013 Aug 14. Proc Natl Acad Sci U S A. 2013. PMID: 23946428 Free PMC article.
IL-32 promotes angiogenesis.
Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. Nold-Petry CA, et al. Among authors: rudloff i. J Immunol. 2014 Jan 15;192(2):589-602. doi: 10.4049/jimmunol.1202802. Epub 2013 Dec 11. J Immunol. 2014. PMID: 24337385 Free PMC article.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. Nold-Petry CA, et al. Among authors: rudloff i. Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2. Nat Immunol. 2015. PMID: 25729923
27 results