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Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.
Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z Jr, Gukovsky I, Gukovskaya AS. Biczo G, et al. Among authors: ruchala p. Gastroenterology. 2018 Feb;154(3):689-703. doi: 10.1053/j.gastro.2017.10.012. Epub 2017 Oct 23. Gastroenterology. 2018. PMID: 29074451 Free PMC article.
Lipid-conjugated Smac analogues.
Micewicz ED, Ratikan JA, Waring AJ, Whitelegge JP, McBride WH, Ruchala P. Micewicz ED, et al. Among authors: ruchala p. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4419-27. doi: 10.1016/j.bmcl.2015.09.017. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26384289 Free PMC article.
Small lipidated anti-obesity compounds derived from neuromedin U.
Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P. Micewicz ED, et al. Among authors: ruchala p. Eur J Med Chem. 2015 Aug 28;101:616-26. doi: 10.1016/j.ejmech.2015.07.020. Epub 2015 Jul 14. Eur J Med Chem. 2015. PMID: 26204509 Free PMC article.
Quantitative Measure of Intestinal Permeability Using Blue Food Coloring.
Angarita SAK, Duarte S, Russell TA, Ruchala P, Elliott IA, Whitelegge JP, Zarrinpar A. Angarita SAK, et al. Among authors: ruchala p. J Surg Res. 2019 Jan;233:20-25. doi: 10.1016/j.jss.2018.07.005. Epub 2018 Jul 27. J Surg Res. 2019. PMID: 30502249 Free PMC article. Clinical Trial.
Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.
Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Khachatoorian R, et al. Among authors: ruchala p. Int J Antimicrob Agents. 2016 Apr;47(4):289-96. doi: 10.1016/j.ijantimicag.2016.01.012. Epub 2016 Mar 2. Int J Antimicrob Agents. 2016. PMID: 27013001 Free PMC article.
68 results