Rubin SM - Search Results

1

PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies.

Kumarasamy V, Gao Z, Zhao B, Jiang B, Rubin SM, Burgess K, Witkiewicz AK, Knudsen ES. Kumarasamy V, et al. Among authors: rubin sm. Br J Cancer. 2023 Oct;129(8):1238-1250. doi: 10.1038/s41416-023-02399-4. Epub 2023 Aug 25. Br J Cancer. 2023. PMID: 37626264

2

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.

Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. Guiley KZ, et al. Among authors: rubin sm. Science. 2019 Dec 13;366(6471):eaaw2106. doi: 10.1126/science.aaw2106. Science. 2019. PMID: 31831640 Free PMC article.

3

CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities.

Knudsen ES, Kumarasamy V, Nambiar R, Pearson JD, Vail P, Rosenheck H, Wang J, Eng K, Bremner R, Schramek D, Rubin SM, Welm AL, Witkiewicz AK. Knudsen ES, et al. Among authors: rubin sm. Cell Rep. 2022 Mar 1;38(9):110448. doi: 10.1016/j.celrep.2022.110448. Cell Rep. 2022. PMID: 35235778 Free PMC article.

4

Cancer takes many paths through G1/S.

Knudsen ES, Witkiewicz AK, Rubin SM. Knudsen ES, et al. Among authors: rubin sm. Trends Cell Biol. 2023 Nov 10:S0962-8924(23)00211-8. doi: 10.1016/j.tcb.2023.10.007. Online ahead of print. Trends Cell Biol. 2023. PMID: 37953123 Review.

5

Cks confers specificity to phosphorylation-dependent CDK signaling pathways.

McGrath DA, Balog ER, Kõivomägi M, Lucena R, Mai MV, Hirschi A, Kellogg DR, Loog M, Rubin SM. McGrath DA, et al. Among authors: rubin sm. Nat Struct Mol Biol. 2013 Dec;20(12):1407-14. doi: 10.1038/nsmb.2707. Epub 2013 Nov 3. Nat Struct Mol Biol. 2013. PMID: 24186063 Free PMC article.

6

A Strategy for Direct Chemical Activation of the Retinoblastoma Protein.

Pye CR, Bray WM, Brown ER, Burke JR, Lokey RS, Rubin SM. Pye CR, et al. Among authors: rubin sm. ACS Chem Biol. 2016 May 20;11(5):1192-7. doi: 10.1021/acschembio.6b00011. Epub 2016 Feb 11. ACS Chem Biol. 2016. PMID: 26845289 Free PMC article.

7

Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.

McGrath DA, Fifield BA, Marceau AH, Tripathi S, Porter LA, Rubin SM. McGrath DA, et al. Among authors: rubin sm. EMBO J. 2017 Aug 1;36(15):2251-2262. doi: 10.15252/embj.201796905. Epub 2017 Jun 30. EMBO J. 2017. PMID: 28666995 Free PMC article.

8

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.

Topacio BR, Zatulovskiy E, Cristea S, Xie S, Tambo CS, Rubin SM, Sage J, Kõivomägi M, Skotheim JM. Topacio BR, et al. Among authors: rubin sm. Mol Cell. 2019 May 16;74(4):758-770.e4. doi: 10.1016/j.molcel.2019.03.020. Epub 2019 Apr 11. Mol Cell. 2019. PMID: 30982746 Free PMC article.

9

Integrating Old and New Paradigms of G1/S Control.

Rubin SM, Sage J, Skotheim JM. Rubin SM, et al. Mol Cell. 2020 Oct 15;80(2):183-192. doi: 10.1016/j.molcel.2020.08.020. Epub 2020 Sep 17. Mol Cell. 2020. PMID: 32946743 Free PMC article. Review.

10

Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting.

Rubin SM, Sage J. Rubin SM, et al. Cell Div. 2013 Nov 21;8(1):13. doi: 10.1186/1747-1028-8-13. Cell Div. 2013. PMID: 24257515 Free PMC article.

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