Rubin EJ - Search Results

1

Pyrazinamide triggers degradation of its target aspartate decarboxylase.

Gopal P, Sarathy JP, Yee M, Ragunathan P, Shin J, Bhushan S, Zhu J, Akopian T, Kandror O, Lim TK, Gengenbacher M, Lin Q, Rubin EJ, Grüber G, Dick T. Gopal P, et al. Among authors: rubin ej. Nat Commun. 2020 Apr 3;11(1):1661. doi: 10.1038/s41467-020-15516-1. Nat Commun. 2020. PMID: 32245967 Free PMC article.

2

The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.

Akopian T, Kandror O, Raju RM, Unnikrishnan M, Rubin EJ, Goldberg AL. Akopian T, et al. Among authors: rubin ej. EMBO J. 2012 Mar 21;31(6):1529-41. doi: 10.1038/emboj.2012.5. Epub 2012 Jan 27. EMBO J. 2012. PMID: 22286948 Free PMC article.

3

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.

Raju RM, Unnikrishnan M, Rubin DH, Krishnamoorthy V, Kandror O, Akopian TN, Goldberg AL, Rubin EJ. Raju RM, et al. Among authors: rubin dh, rubin ej. PLoS Pathog. 2012 Feb;8(2):e1002511. doi: 10.1371/journal.ppat.1002511. Epub 2012 Feb 16. PLoS Pathog. 2012. PMID: 22359499 Free PMC article.

4

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.

Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR. Zheng J, et al. Among authors: rubin ej. J Biol Chem. 2013 Aug 9;288(32):23447-56. doi: 10.1074/jbc.M113.475798. Epub 2013 Jun 18. J Biol Chem. 2013. PMID: 23779105 Free PMC article.

5

Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.

Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL. Akopian T, et al. Among authors: rubin ej. J Biol Chem. 2015 Apr 24;290(17):11008-20. doi: 10.1074/jbc.M114.625640. Epub 2015 Mar 10. J Biol Chem. 2015. PMID: 25759383 Free PMC article.

6

Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.

Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, Dick T. Moreira W, et al. Among authors: rubin ej. mBio. 2015 May 5;6(3):e00253-15. doi: 10.1128/mBio.00253-15. mBio. 2015. PMID: 25944857 Free PMC article.

7

Draft Genome Sequence of Mycobacterium abscessus Bamboo.

Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Dick T. Yee M, et al. Among authors: rubin ej. Genome Announc. 2017 May 18;5(20):e00388-17. doi: 10.1128/genomeA.00388-17. Genome Announc. 2017. PMID: 28522728 Free PMC article.

8

Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity.

Rego EH, Audette RE, Rubin EJ. Rego EH, et al. Among authors: rubin ej. Nature. 2017 Jun 1;546(7656):153-157. doi: 10.1038/nature22361. Epub 2017 May 31. Nature. 2017. PMID: 28569798 Free PMC article.

9

Draft Genome Sequence of Mycobacterium avium 11.

Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Chien JY, Hsueh PR, Dick T. Yee M, et al. Among authors: rubin ej. Genome Announc. 2017 Aug 10;5(32):e00766-17. doi: 10.1128/genomeA.00766-17. Genome Announc. 2017. PMID: 28798178 Free PMC article.

10

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS. Yadon AN, et al. Among authors: rubin ej. Nat Commun. 2017 Sep 19;8(1):588. doi: 10.1038/s41467-017-00721-2. Nat Commun. 2017. PMID: 28928454 Free PMC article.

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