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1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity.
Preston S, Garcia-Bustos J, Hall LG, Martin SD, Le TG, Kundu A, Ghoshal A, Nguyen NH, Jiao Y, Ruan B, Xue L, Huang F, Chang BCH, McGee SL, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB. Preston S, et al. Among authors: ruan b. J Med Chem. 2021 Jan 14;64(1):840-844. doi: 10.1021/acs.jmedchem.0c01793. Epub 2020 Dec 22. J Med Chem. 2021. PMID: 33352050
Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.
Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Jabbar A, Wells TNC, Palmer MJ, Gasser RB, Baell JB. Le TG, et al. Among authors: ruan b. J Med Chem. 2018 Dec 13;61(23):10875-10894. doi: 10.1021/acs.jmedchem.8b01544. Epub 2018 Nov 29. J Med Chem. 2018. PMID: 30403349
Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development.
Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB. Le TG, et al. Among authors: ruan b. J Med Chem. 2019 Jan 24;62(2):1036-1053. doi: 10.1021/acs.jmedchem.8b01789. Epub 2019 Jan 7. J Med Chem. 2019. PMID: 30571110
Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.
Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB. Le TG, et al. Among authors: ruan b. J Med Chem. 2019 Apr 11;62(7):3367-3380. doi: 10.1021/acs.jmedchem.8b01790. Epub 2019 Mar 28. J Med Chem. 2019. PMID: 30875218
503 results