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Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model.
Biochem Biophys Res Commun. 2021 Dec 10;582:100-104. doi: 10.1016/j.bbrc.2021.10.036. Epub 2021 Oct 16.
Biochem Biophys Res Commun. 2021.
PMID: 34700241
Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein.
Roux LN, Petit I, Domart R, Concordet JP, Qu J, Zhou H, Joliot A, Ferrigno O, Aberdam D.
Roux LN, et al.
Stem Cells. 2018 Sep;36(9):1421-1429. doi: 10.1002/stem.2858. Epub 2018 Jul 18.
Stem Cells. 2018.
PMID: 29808941
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Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1MET/APR-246.
Aberdam E, Roux LN, Secrétan PH, Boralevi F, Schlatter J, Morice-Picard F, Sol S, Bodemer C, Missero C, Cisternino S, Aberdam D, Hadj-Rabia S.
Aberdam E, et al. Among authors: roux ln.
Cell Death Dis. 2020 Jan 16;11(1):30. doi: 10.1038/s41419-020-2223-8.
Cell Death Dis. 2020.
PMID: 31949132
Free PMC article.
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The antipsychotropic drug Duloxetine rescues PAX6 haploinsufficiency of mutant limbal stem cells through inhibition of the MEK/ERK signaling pathway.
Dorot O, Roux LN, Zennaro L, Oved K, Bremond-Gignac D, Pichinuk E, Aberdam D.
Dorot O, et al. Among authors: roux ln.
Ocul Surf. 2022 Jan;23:140-142. doi: 10.1016/j.jtos.2021.12.003. Epub 2021 Dec 8.
Ocul Surf. 2022.
PMID: 34890804
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Identification of the regulatory circuit governing corneal epithelial fate determination and disease.
Smits JGA, Cunha DL, Amini M, Bertolin M, Laberthonnière C, Qu J, Owen N, Latta L, Seitz B, Roux LN, Stachon T, Ferrari S, Moosajee M, Aberdam D, Szentmary N, van Heeringen SJ, Zhou H.
Smits JGA, et al. Among authors: roux ln.
PLoS Biol. 2023 Oct 19;21(10):e3002336. doi: 10.1371/journal.pbio.3002336. eCollection 2023 Oct.
PLoS Biol. 2023.
PMID: 37856539
Free PMC article.
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Skin absorption of six performance amines used in metalworking fluids.
Roux LN, Brooks JD, Yeatts JL, Baynes RE.
Roux LN, et al.
J Appl Toxicol. 2015 May;35(5):520-8. doi: 10.1002/jat.3056. Epub 2014 Sep 4.
J Appl Toxicol. 2015.
PMID: 25186650
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