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Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage.
Petropoulos M, Champeris Tsaniras S, Nikou S, Maxouri S, Dionellis VS, Kalogeropoulou A, Karamichali A, Ioannidis K, Danalatos IR, Obst M, Naumann R, Delinasios GJ, Gorgoulis VG, Roukos V, Anastassiadis K, Halazonetis TD, Bravou V, Lygerou Z, Taraviras S. Petropoulos M, et al. Among authors: roukos v. J Pathol. 2023 Jan;259(1):10-20. doi: 10.1002/path.6017. Epub 2022 Nov 9. J Pathol. 2023. PMID: 36210634
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T. Nishitani H, et al. Among authors: roukos v. EMBO J. 2006 Mar 8;25(5):1126-36. doi: 10.1038/sj.emboj.7601002. Epub 2006 Feb 16. EMBO J. 2006. PMID: 16482215 Free PMC article.
Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage.
Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, Lygerou Z. Roukos V, et al. J Cell Sci. 2011 Feb 1;124(Pt 3):422-34. doi: 10.1242/jcs.074229. Epub 2011 Jan 11. J Cell Sci. 2011. PMID: 21224399
53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling.
Tsaridou S, Velimezi G, Willenbrock F, Chatzifrangkeskou M, Elsayed W, Panagopoulos A, Karamitros D, Gorgoulis V, Lygerou Z, Roukos V, O'Neill E, Pefani DE. Tsaridou S, et al. Among authors: roukos v. EMBO Rep. 2022 Aug 3;23(8):e54483. doi: 10.15252/embr.202154483. Epub 2022 Jun 27. EMBO Rep. 2022. PMID: 35758159 Free PMC article.
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.
Zhang N, Harbers L, Simonetti M, Diekmann C, Verron Q, Berrino E, Bellomo SE, Longo GMC, Ratz M, Schultz N, Tarish F, Su P, Han B, Wang W, Onorato S, Grassini D, Ballarino R, Giordano S, Yang Q, Sapino A, Frisén J, Alkass K, Druid H, Roukos V, Helleday T, Marchiò C, Bienko M, Crosetto N. Zhang N, et al. Among authors: roukos v. Nat Commun. 2024 Apr 24;15(1):3475. doi: 10.1038/s41467-024-47664-z. Nat Commun. 2024. PMID: 38658552 Free PMC article.
36 results