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Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.
Cook DP, Cunha JPMCM, Martens PJ, Sassi G, Mancarella F, Ventriglia G, Sebastiani G, Vanherwegen AS, Atkinson MA, Van Huynegem K, Steidler L, Caluwaerts S, Rottiers P, Teyton L, Dotta F, Gysemans C, Mathieu C. Cook DP, et al. Among authors: rottiers p. Front Immunol. 2020 Jun 9;11:1103. doi: 10.3389/fimmu.2020.01103. eCollection 2020. Front Immunol. 2020. PMID: 32582188 Free PMC article.
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.
Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, van Deventer SJ, Neirynck S, Peppelenbosch MP, Steidler L. Braat H, et al. Among authors: rottiers p. Clin Gastroenterol Hepatol. 2006 Jun;4(6):754-9. doi: 10.1016/j.cgh.2006.03.028. Epub 2006 May 22. Clin Gastroenterol Hepatol. 2006. PMID: 16716759 Clinical Trial.
A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner.
Coppieters K, Van Beneden K, Jacques P, Dewint P, Vervloet A, Vander Cruyssen B, Van Calenbergh S, Chen G, Franck RW, Verbruggen G, Deforce D, Matthys P, Tsuji M, Rottiers P, Elewaut D. Coppieters K, et al. Among authors: rottiers p. J Immunol. 2007 Aug 15;179(4):2300-9. doi: 10.4049/jimmunol.179.4.2300. J Immunol. 2007. PMID: 17675491
Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered immunodominant DQ8-restricted gliadin peptide in sensitized nonobese diabetic Abo Dq8 transgenic mice.
Huibregtse IL, Marietta EV, Rashtak S, Koning F, Rottiers P, David CS, van Deventer SJ, Murray JA. Huibregtse IL, et al. Among authors: rottiers p. J Immunol. 2009 Aug 15;183(4):2390-6. doi: 10.4049/jimmunol.0802891. Epub 2009 Jul 27. J Immunol. 2009. PMID: 19635921 Free PMC article.
45 results