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HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial.
Bakker NAM, Rotman J, van Beurden M, Zijlmans HJM, van Ruiten M, Samuels S, Nuijen B, Beijnen J, De Visser K, Haanen J, Schumacher T, de Gruijl TD, Jordanova ES, Kenter GG, van den Berg JH, van Trommel NE. Bakker NAM, et al. Among authors: rotman j. J Immunother Cancer. 2021 Aug;9(8):e002547. doi: 10.1136/jitc-2021-002547. J Immunother Cancer. 2021. PMID: 34341131 Free PMC article. Clinical Trial.
Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels.
Heeren AM, Rotman J, Stam AGM, Pocorni N, Gassama AA, Samuels S, Bleeker MCG, Mom CH, Zijlmans HJMAA, Kenter GG, Jordanova ES, de Gruijl TD. Heeren AM, et al. Among authors: rotman j. J Immunother Cancer. 2019 Feb 12;7(1):43. doi: 10.1186/s40425-019-0526-z. J Immunother Cancer. 2019. PMID: 30755279 Free PMC article.
Adenocarcinoma of the Uterine Cervix Shows Impaired Recruitment of cDC1 and CD8+ T Cells and Elevated β-Catenin Activation Compared with Squamous Cell Carcinoma.
Rotman J, Heeren AM, Gassama AA, Lougheed SM, Pocorni N, Stam AGM, Bleeker MCG, Zijlmans HJMAA, Mom CH, Kenter GG, Jordanova ES, de Gruijl TD. Rotman J, et al. Clin Cancer Res. 2020 Jul 15;26(14):3791-3802. doi: 10.1158/1078-0432.CCR-19-3826. Epub 2020 Mar 27. Clin Cancer Res. 2020. PMID: 32220890
Delta-Like Ligand-Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis.
Khelil M, Griffin H, Bleeker MCG, Steenbergen RDM, Zheng K, Saunders-Wood T, Samuels S, Rotman J, Vos W, van den Akker BE, de Menezes RX, Kenter GG, Doorbar J, Jordanova ES. Khelil M, et al. Among authors: rotman j. Cancer Res. 2021 Apr 1;81(7):1909-1921. doi: 10.1158/0008-5472.CAN-20-1996. Epub 2021 Jan 26. Cancer Res. 2021. PMID: 33500246
PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential.
Rotman J, den Otter LAS, Bleeker MCG, Samuels SS, Heeren AM, Roemer MGM, Kenter GG, Zijlmans HJMAA, van Trommel NE, de Gruijl TD, Jordanova ES. Rotman J, et al. Front Immunol. 2020 Dec 17;11:596825. doi: 10.3389/fimmu.2020.596825. eCollection 2020. Front Immunol. 2020. PMID: 33424844 Free PMC article.
RNA-seq data science: From raw data to effective interpretation.
Deshpande D, Chhugani K, Chang Y, Karlsberg A, Loeffler C, Zhang J, Muszyńska A, Munteanu V, Yang H, Rotman J, Tao L, Balliu B, Tseng E, Eskin E, Zhao F, Mohammadi P, P Łabaj P, Mangul S. Deshpande D, et al. Among authors: rotman j. Front Genet. 2023 Mar 13;14:997383. doi: 10.3389/fgene.2023.997383. eCollection 2023. Front Genet. 2023. PMID: 36999049 Free PMC article. Review.
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