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Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.
Marchal GA, Jouni M, Chiang DY, Pérez-Hernández M, Podliesna S, Yu N, Casini S, Potet F, Veerman CC, Klerk M, Lodder EM, Mengarelli I, Guan K, Vanoye CG, Rothenberg E, Charpentier F, Redon R, George AL Jr, Verkerk AO, Bezzina CR, MacRae CA, Burridge PW, Delmar M, Galjart N, Portero V, Remme CA. Marchal GA, et al. Among authors: rothenberg e. Circ Res. 2021 Jul 23;129(3):349-365. doi: 10.1161/CIRCRESAHA.120.318643. Epub 2021 Jun 7. Circ Res. 2021. PMID: 34092082 Free PMC article.
Structural and Functional Characterization of a Nav1.5-Mitochondrial Couplon.
Pérez-Hernández M, Leo-Macias A, Keegan S, Jouni M, Kim JC, Agullo-Pascual E, Vermij S, Zhang M, Liang FX, Burridge P, Fenyo D, Rothenberg E, Delmar M. Pérez-Hernández M, et al. Among authors: rothenberg e. Circ Res. 2021 Feb 5;128(3):419-432. doi: 10.1161/CIRCRESAHA.120.318239. Epub 2020 Dec 21. Circ Res. 2021. PMID: 33342222 Free PMC article.
Disruption of Ca2+i Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice.
Kim JC, Pérez-Hernández M, Alvarado FJ, Maurya SR, Montnach J, Yin Y, Zhang M, Lin X, Vasquez C, Heguy A, Liang FX, Woo SH, Morley GE, Rothenberg E, Lundby A, Valdivia HH, Cerrone M, Delmar M. Kim JC, et al. Among authors: rothenberg e. Circulation. 2019 Sep 17;140(12):1015-1030. doi: 10.1161/CIRCULATIONAHA.119.039710. Epub 2019 Jul 18. Circulation. 2019. PMID: 31315456 Free PMC article.
Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC.
Pérez-Hernández M, van Opbergen CJM, Bagwan N, Vissing CR, Marrón-Liñares GM, Zhang M, Torres Vega E, Sorrentino A, Drici L, Sulek K, Zhai R, Hansen FB, Christensen AH, Boesgaard S, Gustafsson F, Rossing K, Small EM, Davies MJ, Rothenberg E, Sato PY, Cerrone M, Jensen THL, Qvortrup K, Bundgaard H, Delmar M, Lundby A. Pérez-Hernández M, et al. Among authors: rothenberg e. Circulation. 2022 Sep 13;146(11):851-867. doi: 10.1161/CIRCULATIONAHA.122.060454. Epub 2022 Aug 12. Circulation. 2022. PMID: 35959657 Free PMC article.
Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.
Cerrone M, Lin X, Zhang M, Agullo-Pascual E, Pfenniger A, Chkourko Gusky H, Novelli V, Kim C, Tirasawadichai T, Judge DP, Rothenberg E, Chen HS, Napolitano C, Priori SG, Delmar M. Cerrone M, et al. Among authors: rothenberg e. Circulation. 2014 Mar 11;129(10):1092-103. doi: 10.1161/CIRCULATIONAHA.113.003077. Epub 2013 Dec 18. Circulation. 2014. PMID: 24352520 Free PMC article.
Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.
Agullo-Pascual E, Lin X, Leo-Macias A, Zhang M, Liang FX, Li Z, Pfenniger A, Lübkemeier I, Keegan S, Fenyö D, Willecke K, Rothenberg E, Delmar M. Agullo-Pascual E, et al. Among authors: rothenberg e. Cardiovasc Res. 2014 Nov 1;104(2):371-81. doi: 10.1093/cvr/cvu195. Epub 2014 Aug 18. Cardiovasc Res. 2014. PMID: 25139742 Free PMC article.
Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.
Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA Jr, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM. Trembley MA, et al. Among authors: rothenberg e. Circulation. 2018 Oct 23;138(17):1864-1878. doi: 10.1161/CIRCULATIONAHA.117.031788. Circulation. 2018. PMID: 29716942 Free PMC article.
378 results