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Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.
Tschuck J, Theilacker L, Rothenaigner I, Weiß SAI, Akdogan B, Lam VT, Müller C, Graf R, Brandner S, Pütz C, Rieder T, Schmitt-Kopplin P, Vincendeau M, Zischka H, Schorpp K, Hadian K. Tschuck J, et al. Among authors: rothenaigner i. Nat Commun. 2023 Oct 30;14(1):6908. doi: 10.1038/s41467-023-42702-8. Nat Commun. 2023. PMID: 37903763 Free PMC article.
Image-based high-content screening in drug discovery.
Lin S, Schorpp K, Rothenaigner I, Hadian K. Lin S, et al. Among authors: rothenaigner i. Drug Discov Today. 2020 Aug;25(8):1348-1361. doi: 10.1016/j.drudis.2020.06.001. Epub 2020 Jun 16. Drug Discov Today. 2020. PMID: 32561299 Review.
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
Iturbide A, Ruiz Tejada Segura ML, Noll C, Schorpp K, Rothenaigner I, Ruiz-Morales ER, Lubatti G, Agami A, Hadian K, Scialdone A, Torres-Padilla ME. Iturbide A, et al. Among authors: rothenaigner i. Nat Struct Mol Biol. 2021 Jun;28(6):521-532. doi: 10.1038/s41594-021-00590-w. Epub 2021 May 27. Nat Struct Mol Biol. 2021. PMID: 34045724 Free PMC article.
New small molecules targeting apoptosis and cell viability in osteosarcoma.
Maugg D, Rothenaigner I, Schorpp K, Potukuchi HK, Korsching E, Baumhoer D, Hadian K, Smida J, Nathrath M. Maugg D, et al. Among authors: rothenaigner i. PLoS One. 2015 Jun 3;10(6):e0129058. doi: 10.1371/journal.pone.0129058. eCollection 2015. PLoS One. 2015. PMID: 26039064 Free PMC article.
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K. Brenke JK, et al. Among authors: rothenaigner i. J Biol Chem. 2018 Aug 24;293(34):13191-13203. doi: 10.1074/jbc.RA118.002649. Epub 2018 Jun 27. J Biol Chem. 2018. PMID: 29950522 Free PMC article.
27 results