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Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.
Roth Flach RJ, Bollinger E, Reyes AR, Laforest B, Kormos BL, Liu S, Reese MR, Martinez Alsina LA, Buzon L, Zhang Y, Bechle B, Rosado A, Sahasrabudhe PV, Knafels J, Bhattacharya SK, Omoto K, Stansfield JC, Hurley LD, Song L, Luo L, Breitkopf SB, Monetti M, Cunio T, Tierney B, Geoly FJ, Delmore J, Siddall CP, Xue L, Yip KN, Kalgutkar AS, Miller RA, Zhang BB, Filipski KJ. Roth Flach RJ, et al. Nat Commun. 2023 Aug 9;14(1):4812. doi: 10.1038/s41467-023-40536-y. Nat Commun. 2023. PMID: 37558654 Free PMC article.
Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
Liu S, Kormos BL, Knafels JD, Sahasrabudhe PV, Rosado A, Sommese RF, Reyes AR, Ward J, Roth Flach RJ, Wang X, Buzon LM, Reese MR, Bhattacharya SK, Omoto K, Filipski KJ. Liu S, et al. Among authors: roth flach rj. J Biol Chem. 2023 Mar;299(3):102959. doi: 10.1016/j.jbc.2023.102959. Epub 2023 Jan 28. J Biol Chem. 2023. PMID: 36717078 Free PMC article.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ. Bollinger E, et al. Among authors: roth flach rj. Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8. Mol Metab. 2022. PMID: 36220546 Free PMC article.
An assessment of thermoneutral housing conditions on murine cardiometabolic function.
Chen X, Bollinger E, Cunio T, Damilano F, Stansfield JC, Pinkus CA, Kreuser S, Hirenallur-Shanthappa D, Roth Flach RJ. Chen X, et al. Among authors: roth flach rj. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H234-H245. doi: 10.1152/ajpheart.00461.2021. Epub 2021 Dec 17. Am J Physiol Heart Circ Physiol. 2022. PMID: 34919456 Free article.
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.
Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995. doi: 10.1038/ncomms9995. Nat Commun. 2015. PMID: 26688060 Free PMC article.
Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition.
Roth Flach RJ, Su C, Bollinger E, Cortes C, Robertson AW, Opsahl AC, Coskran TM, Maresca KP, Keliher EJ, Yates PD, Kim AM, Kalgutkar AS, Buckbinder L. Roth Flach RJ, et al. PLoS One. 2019 Mar 19;14(3):e0214150. doi: 10.1371/journal.pone.0214150. eCollection 2019. PLoS One. 2019. PMID: 30889221 Free PMC article.
Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension.
Song L, Chen X, Swanson TA, LaViolette B, Pang J, Cunio T, Nagle MW, Asano S, Hales K, Shipstone A, Sobon H, Al-Harthy SD, Ahn Y, Kreuser S, Robertson A, Ritenour C, Voigt F, Boucher M, Sun F, Sessa WC, Roth Flach RJ. Song L, et al. Among authors: roth flach rj. Elife. 2020 Nov 17;9:e58376. doi: 10.7554/eLife.58376. Elife. 2020. PMID: 33200983 Free PMC article.
Peripartum Cardiomyopathy: Is It All in the Timing?
Roth Flach RJ, Khankin EV. Roth Flach RJ, et al. Hypertension. 2020 Jan;75(1):33-34. doi: 10.1161/HYPERTENSIONAHA.119.13742. Epub 2019 Nov 11. Hypertension. 2020. PMID: 31707839 No abstract available.
21 results