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Page 1
Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts.
Sperotto NDM, Silva RBM, Perelló MA, Borsoi AF, da Silva Dadda A, Roth CD, Freitas RDS, de Souza APD, Freitas DDN, Picada JN, de Sousa JT, Nabinger DD, Altenhofen S, Bonan CD, Rodrigues-Junior VS, Bizarro CV, Basso LA, Machado P. Sperotto NDM, et al. Among authors: roth cd. Biomed Pharmacother. 2021 Jul;139:111672. doi: 10.1016/j.biopha.2021.111672. Epub 2021 May 6. Biomed Pharmacother. 2021. PMID: 33965731 Free article.
8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in vitro inhibition and docking studies.
Czeczot AM, Roth CD, Ducati RG, Pissinate K, Rambo RS, Timmers LFSM, Abbadi BL, Macchi FS, Pestana VZ, Basso LA, Machado P, Bizarro CV. Czeczot AM, et al. Among authors: roth cd. J Enzyme Inhib Med Chem. 2021 Dec;36(1):847-855. doi: 10.1080/14756366.2021.1900157. J Enzyme Inhib Med Chem. 2021. PMID: 33752554 Free PMC article.
EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis.
Duque-Villegas MA, Abbadi BL, Romero PR, Matter LB, Galina L, Dalberto PF, Rodrigues-Junior VDS, Ducati RG, Roth CD, Rambo RS, de Souza EV, Perello MA, Morbidoni HR, Machado P, Basso LA, Bizarro CV. Duque-Villegas MA, et al. Among authors: roth cd. Microbiol Spectr. 2021 Dec 22;9(3):e0000921. doi: 10.1128/Spectrum.00009-21. Epub 2021 Dec 22. Microbiol Spectr. 2021. PMID: 34937164 Free PMC article.
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, Madeira Silva RB, Perelló MA, de Matos Czeczot A, Neves CE, Duarte LS, Leyser M, Dias de Oliveira S, Bizarro CV, Machado P, Basso LA. Paz JD, et al. Among authors: roth cd. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. doi: 10.1016/j.ejmech.2022.114908. Epub 2022 Nov 18. Eur J Med Chem. 2023. PMID: 36435016
Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments.
Freitas de Freitas T, Roth CD, Abbadi BL, Hopf FSM, Perelló MA, de Matos Czeczot A, de Souza EV, Borsoi AF, Machado P, Bizarro CV, Basso LA, Timmers LFSM. Freitas de Freitas T, et al. Among authors: roth cd. J Comput Aided Mol Des. 2023 Mar;37(3):117-128. doi: 10.1007/s10822-022-00495-w. Epub 2022 Dec 22. J Comput Aided Mol Des. 2023. PMID: 36547753 Free PMC article.