Roth BL - Search Results

1

Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.

Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL. Krumm BE, et al. Among authors: roth bl. Biochemistry. 2023 Apr 4;62(7):1233-1248. doi: 10.1021/acs.biochem.3c00029. Epub 2023 Mar 14. Biochemistry. 2023. PMID: 36917754

2

Screening the receptorome: an efficient approach for drug discovery and target validation.

Strachan RT, Ferrara G, Roth BL. Strachan RT, et al. Among authors: roth bl. Drug Discov Today. 2006 Aug;11(15-16):708-16. doi: 10.1016/j.drudis.2006.06.012. Drug Discov Today. 2006. PMID: 16846798 Review.

3

N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.

Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. Jensen NH, et al. Among authors: roth bl. Neuropsychopharmacology. 2008 Sep;33(10):2303-12. doi: 10.1038/sj.npp.1301646. Epub 2007 Dec 5. Neuropsychopharmacology. 2008. PMID: 18059438

4

Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling.

Strachan RT, Sheffler DJ, Willard B, Kinter M, Kiselar JG, Roth BL. Strachan RT, et al. Among authors: roth bl. J Biol Chem. 2009 Feb 27;284(9):5557-73. doi: 10.1074/jbc.M805705200. Epub 2008 Dec 22. J Biol Chem. 2009. PMID: 19103592 Free PMC article.

5

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: roth bl. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

6

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment.

Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL. Huang XP, et al. Among authors: roth bl. Mol Pharmacol. 2009 Oct;76(4):710-22. doi: 10.1124/mol.109.058057. Epub 2009 Jul 1. Mol Pharmacol. 2009. PMID: 19570945 Free PMC article.

7

Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.

Strachan RT, Sciaky N, Cronan MR, Kroeze WK, Roth BL. Strachan RT, et al. Among authors: roth bl. Mol Pharmacol. 2010 Mar;77(3):327-38. doi: 10.1124/mol.109.061440. Epub 2009 Nov 20. Mol Pharmacol. 2010. PMID: 19933401 Free PMC article.

8

p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.

Strachan RT, Allen JA, Sheffler DJ, Roth BL. Strachan RT, et al. Among authors: roth bl. Biochemistry. 2010 Mar 30;49(12):2657-71. doi: 10.1021/bi901921k. Biochemistry. 2010. PMID: 20136148 Free PMC article.

9

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Hajjo R, et al. Among authors: roth bl. J Med Chem. 2010 Nov 11;53(21):7573-86. doi: 10.1021/jm100600y. J Med Chem. 2010. PMID: 20958049 Free PMC article.

10

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Among authors: roth bl. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.

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