Rossotti MA - Search Results

1

Immunogenicity and humanization of single-domain antibodies.

Rossotti MA, Bélanger K, Henry KA, Tanha J. Rossotti MA, et al. FEBS J. 2022 Jul;289(14):4304-4327. doi: 10.1111/febs.15809. Epub 2021 Mar 25. FEBS J. 2022. PMID: 33751827 Free article. Review.

2

A disulfide-stabilized human V_L single-domain antibody library is a source of soluble and highly thermostable binders.

Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J. Henry KA, et al. Among authors: rossotti ma. Mol Immunol. 2017 Oct;90:190-196. doi: 10.1016/j.molimm.2017.07.006. Epub 2017 Aug 15. Mol Immunol. 2017. PMID: 28820969

3

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.

Rossotti MA, Henry KA, van Faassen H, Tanha J, Callaghan D, Hussack G, Arbabi-Ghahroudi M, MacKenzie CR. Rossotti MA, et al. Biochem J. 2019 Jan 7;476(1):39-50. doi: 10.1042/BCJ20180795. Biochem J. 2019. PMID: 30455372

4

Modulating antibody-dependent cellular cytotoxicity of epidermal growth factor receptor-specific heavy-chain antibodies through hinge engineering.

D'Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J. D'Eall C, et al. Among authors: rossotti ma. Immunol Cell Biol. 2019 Jul;97(6):526-537. doi: 10.1111/imcb.12238. Epub 2019 Mar 3. Immunol Cell Biol. 2019. PMID: 30680791

5

Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains.

Hussack G, Ryan S, van Faassen H, Rossotti M, MacKenzie CR, Tanha J. Hussack G, et al. PLoS One. 2018 Dec 12;13(12):e0208978. doi: 10.1371/journal.pone.0208978. eCollection 2018. PLoS One. 2018. PMID: 30540857 Free PMC article.

6

Immunological Functions and Evolutionary Emergence of Heavy-Chain Antibodies.

Brooks CL, Rossotti MA, Henry KA. Brooks CL, et al. Among authors: rossotti ma. Trends Immunol. 2018 Dec;39(12):956-960. doi: 10.1016/j.it.2018.09.008. Epub 2018 Oct 10. Trends Immunol. 2018. PMID: 30314850 Review.

7

Serum albumin-binding V_H Hs with variable pH sensitivities enable tailored half-life extension of biologics.

van Faassen H, Ryan S, Henry KA, Raphael S, Yang Q, Rossotti MA, Brunette E, Jiang S, Haqqani AS, Sulea T, MacKenzie CR, Tanha J, Hussack G. van Faassen H, et al. Among authors: rossotti ma. FASEB J. 2020 Jun;34(6):8155-8171. doi: 10.1096/fj.201903231R. Epub 2020 Apr 28. FASEB J. 2020. PMID: 32342547

8

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models.

Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, Matte K, Laroche G, Giguère PM, Gervais C, Stuible M, Guimond J, Perret S, Hussack G, Langlois MA, Durocher Y, Tanha J. Rossotti MA, et al. Commun Biol. 2022 Sep 9;5(1):933. doi: 10.1038/s42003-022-03866-z. Commun Biol. 2022. PMID: 36085335 Free PMC article.

9

Development and Characterization of Mouse Monoclonal Antibodies Specific for Clostridiodes (Clostridium) difficile Lipoteichoic Acid.

Cairns CM, van Faassen H, St Michael F, Aubry A, Henry KA, Rossotti MA, Logan SM, Hussack G, Gisch N, Hogendorf WFJ, Pedersen CM, Cox AD. Cairns CM, et al. Among authors: rossotti ma. ACS Chem Biol. 2020 Apr 17;15(4):1050-1058. doi: 10.1021/acschembio.0c00066. Epub 2020 Apr 1. ACS Chem Biol. 2020. PMID: 32191024

10

Llama DNA Immunization and Isolation of Functional Single-Domain Antibody Binders.

Trempe F, Rossotti MA, Maqbool T, MacKenzie CR, Arbabi-Ghahroudi M. Trempe F, et al. Among authors: rossotti ma. Methods Mol Biol. 2022;2446:37-70. doi: 10.1007/978-1-0716-2075-5_3. Methods Mol Biol. 2022. PMID: 35157268

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