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Highly efficient asymmetric synthesis of sitagliptin.
Hansen KB, Hsiao Y, Xu F, Rivera N, Clausen A, Kubryk M, Krska S, Rosner T, Simmons B, Balsells J, Ikemoto N, Sun Y, Spindler F, Malan C, Grabowski EJ, Armstrong JD 3rd. Hansen KB, et al. Among authors: rosner t. J Am Chem Soc. 2009 Jul 1;131(25):8798-804. doi: 10.1021/ja902462q. J Am Chem Soc. 2009. PMID: 19507853
Correction to "Highly Efficient Asymmetric Synthesis of Sitagliptin".
Hansen KB, Hsiao Y, Xu F, Rivera N, Clausen A, Kubryk M, Krska S, Rosner T, Simmons B, Balsells J, Ikemoto N, Sun Y, Spindler F, Malan C, Grabowski EJJ, Armstrong JD 3rd. Hansen KB, et al. Among authors: rosner t. J Am Chem Soc. 2020 Aug 5;142(31):13622. doi: 10.1021/jacs.0c06041. Epub 2020 Jul 24. J Am Chem Soc. 2020. PMID: 32706576 No abstract available.
Efficient and scalable enantioselective synthesis of a CGRP antagonist.
Leahy DK, Fan Y, Desai LV, Chan C, Zhu J, Luo G, Chen L, Hanson RL, Sugiyama M, Rosner T, Cuniere N, Guo Z, Hsiao Y, Gao Q. Leahy DK, et al. Among authors: rosner t. Org Lett. 2012 Sep 21;14(18):4938-41. doi: 10.1021/ol302262q. Epub 2012 Sep 6. Org Lett. 2012. PMID: 22954228
An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction.
Song ZJ, King AO, Waters MS, Lang F, Zewge D, Bio M, Leazer JL Jr, Javadi G, Kassim A, Tschaen DM, Reamer RA, Rosner T, Chilenski JR, Mathre DJ, Volante RP, Tillyer R. Song ZJ, et al. Among authors: rosner t. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5776-81. doi: 10.1073/pnas.0307415101. Epub 2004 Apr 12. Proc Natl Acad Sci U S A. 2004. PMID: 15079059 Free PMC article.
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.
Degnan AP, Tora GO, Huang H, Conlon DA, Davis CD, Hanumegowda UM, Hou X, Hsiao Y, Hu J, Krause R, Li YW, Newton AE, Pieschl RL, Raybon J, Rosner T, Sun JH, Taber MT, Taylor SJ, Wong MK, Zhang H, Lodge NJ, Bronson JJ, Macor JE, Gillman KW. Degnan AP, et al. Among authors: rosner t. ACS Chem Neurosci. 2016 Dec 21;7(12):1635-1640. doi: 10.1021/acschemneuro.6b00337. Epub 2016 Oct 18. ACS Chem Neurosci. 2016. PMID: 27744678
C-H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543.
Fox RJ, Cuniere NL, Bakrania L, Wei C, Strotman NA, Hay M, Fanfair D, Regens C, Beutner GL, Lawler M, Lobben P, Soumeillant MC, Cohen B, Zhu K, Skliar D, Rosner T, Markwalter CE, Hsiao Y, Tran K, Eastgate MD. Fox RJ, et al. Among authors: rosner t. J Org Chem. 2019 Apr 19;84(8):4661-4669. doi: 10.1021/acs.joc.8b02383. Epub 2018 Nov 12. J Org Chem. 2019. PMID: 30388009
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