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Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses.
Tampere M, Pettke A, Salata C, Wallner O, Koolmeister T, Cazares-Körner A, Visnes T, Hesselman MC, Kunold E, Wiita E, Kalderén C, Lightowler M, Jemth AS, Lehtiö J, Rosenquist Å, Warpman-Berglund U, Helleday T, Mirazimi A, Jafari R, Puumalainen MR. Tampere M, et al. Among authors: rosenquist a. Viruses. 2020 Dec 10;12(12):1423. doi: 10.3390/v12121423. Viruses. 2020. PMID: 33322045 Free PMC article.
Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.
Rosenquist Å, Samuelsson B, Johansson PO, Cummings MD, Lenz O, Raboisson P, Simmen K, Vendeville S, de Kock H, Nilsson M, Horvath A, Kalmeijer R, de la Rosa G, Beumont-Mauviel M. Rosenquist Å, et al. J Med Chem. 2014 Mar 13;57(5):1673-93. doi: 10.1021/jm401507s. Epub 2014 Feb 14. J Med Chem. 2014. PMID: 24446688
Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy.
Lindberg J, Pyring D, Löwgren S, Rosenquist A, Zuccarello G, Kvarnström I, Zhang H, Vrang L, Classon B, Hallberg A, Samuelsson B, Unge T. Lindberg J, et al. Among authors: rosenquist a. Eur J Biochem. 2004 Nov;271(22):4594-602. doi: 10.1111/j.1432-1033.2004.04431.x. Eur J Biochem. 2004. PMID: 15560801 Free article.
2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.
Jonckers TH, Lin TI, Buyck C, Lachau-Durand S, Vandyck K, Van Hoof S, Vandekerckhove LA, Hu L, Berke JM, Vijgen L, Dillen LL, Cummings MD, de Kock H, Nilsson M, Sund C, Rydegård C, Samuelsson B, Rosenquist A, Fanning G, Van Emelen K, Simmen K, Raboisson P. Jonckers TH, et al. Among authors: rosenquist a. J Med Chem. 2010 Nov 25;53(22):8150-60. doi: 10.1021/jm101050a. Epub 2010 Oct 29. J Med Chem. 2010. PMID: 21033671
P2'-truncated BACE-1 inhibitors with a novel hydroxethylene-like core.
Meredith JA, Björklund C, Adolfsson H, Jansson K, Hallberg A, Rosenquist A, Samuelsson B. Meredith JA, et al. Among authors: rosenquist a. Eur J Med Chem. 2010 Feb;45(2):542-54. doi: 10.1016/j.ejmech.2009.10.041. Epub 2009 Nov 3. Eur J Med Chem. 2010. PMID: 19995674
Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.
Jonckers TH, Vandyck K, Vandekerckhove L, Hu L, Tahri A, Van Hoof S, Lin TI, Vijgen L, Berke JM, Lachau-Durand S, Stoops B, Leclercq L, Fanning G, Samuelsson B, Nilsson M, Rosenquist Å, Simmen K, Raboisson P. Jonckers TH, et al. Among authors: rosenquist a. J Med Chem. 2014 Mar 13;57(5):1836-44. doi: 10.1021/jm4015422. Epub 2014 Jan 6. J Med Chem. 2014. PMID: 24345201
3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists.
Semple G, Andersson BM, Chhajlani V, Georgsson J, Johansson M, Lindschoten M, Pontén F, Rosenquist A, Sörensen H, Swanson L, Swanson M. Semple G, et al. Among authors: rosenquist a. Bioorg Med Chem Lett. 2002 Jan 21;12(2):197-200. doi: 10.1016/s0960-894x(01)00691-6. Bioorg Med Chem Lett. 2002. PMID: 11755353
94 results