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Animal and model systems for studying cystic fibrosis.
Rosen BH, Chanson M, Gawenis LR, Liu J, Sofoluwe A, Zoso A, Engelhardt JF. Rosen BH, et al. J Cyst Fibros. 2018 Mar;17(2S):S28-S34. doi: 10.1016/j.jcf.2017.09.001. Epub 2017 Sep 19. J Cyst Fibros. 2018. PMID: 28939349 Free PMC article. Review.
Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets.
Rosen BH, Evans TIA, Moll SR, Gray JS, Liang B, Sun X, Zhang Y, Jensen-Cody CW, Swatek AM, Zhou W, He N, Rotti PG, Tyler SR, Keiser NW, Anderson PJ, Brooks L, Li Y, Pope RM, Rajput M, Hoffman EA, Wang K, Harris JK, Parekh KR, Gibson-Corley KN, Engelhardt JF. Rosen BH, et al. Am J Respir Crit Care Med. 2018 May 15;197(10):1308-1318. doi: 10.1164/rccm.201708-1616OC. Am J Respir Crit Care Med. 2018. PMID: 29327941 Free PMC article.
In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.
Sun X, Yi Y, Yan Z, Rosen BH, Liang B, Winter MC, Evans TIA, Rotti PG, Yang Y, Gray JS, Park SY, Zhou W, Zhang Y, Moll SR, Woody L, Tran DM, Jiang L, Vonk AM, Beekman JM, Negulescu P, Van Goor F, Fiorino DF, Gibson-Corley KN, Engelhardt JF. Sun X, et al. Among authors: rosen bh. Sci Transl Med. 2019 Mar 27;11(485):eaau7531. doi: 10.1126/scitranslmed.aau7531. Sci Transl Med. 2019. PMID: 30918114 Free PMC article.
A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.
Fernandez-Petty CM, Hughes GW, Bowers HL, Watson JD, Rosen BH, Townsend SM, Santos C, Ridley CE, Chu KK, Birket SE, Li Y, Leung HM, Mazur M, Garcia BA, Evans TIA, Libby EF, Hathorne H, Hanes J, Tearney GJ, Clancy JP, Engelhardt JF, Swords WE, Thornton DJ, Wiesmann WP, Baker SM, Rowe SM. Fernandez-Petty CM, et al. Among authors: rosen bh. JCI Insight. 2019 Apr 18;4(8):e125954. doi: 10.1172/jci.insight.125954. eCollection 2019 Apr 18. JCI Insight. 2019. PMID: 30996141 Free PMC article.
Ferret models of alpha-1 antitrypsin deficiency develop lung and liver disease.
He N, Liu X, Vegter AR, Evans TIA, Gray JS, Guo J, Moll SR, Guo LJ, Luo M, Ma N, Sun X, Liang B, Yan Z, Feng Z, Qi L, Joshi AS, Shahin W, Yi Y, Gibson-Corley KN, Hoffman EA, Wang K, Mueller C, Engelhardt JF, Rosen BH. He N, et al. Among authors: rosen bh. JCI Insight. 2022 Mar 8;7(5):e143004. doi: 10.1172/jci.insight.143004. JCI Insight. 2022. PMID: 35104244 Free PMC article.
Transgenic ferret models define pulmonary ionocyte diversity and function.
Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, Dick DW, Wadas TJ, Joo NS, Wine JJ, Birket S, Fernandez CM, Leung HM, Tearney GJ, Verkman AS, Haggie PM, Scott K, Bartels D, Meyerholz DK, Rowe SM, Liu X, Yan Z, Haber AL, Sun X, Engelhardt JF. Yuan F, et al. Among authors: rosen bh. Nature. 2023 Sep;621(7980):857-867. doi: 10.1038/s41586-023-06549-9. Epub 2023 Sep 20. Nature. 2023. PMID: 37730992 Free PMC article.
In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets.
Evans IA, Sun X, Liang B, Vegter AR, Guo L, Lynch TJ, Zhang Y, Zhang Y, Yi Y, Yang Y, Feng Z, Park SY, Shonka A, McCumber H, Qi L, Wu P, Liu G, Lacina A, Wang K, Gibson-Corley KN, Meyerholz DK, Limoli DH, Rosen BH, Yan Z, Bartels DJ, Engelhardt JF. Evans IA, et al. Among authors: rosen bh. JCI Insight. 2024 Apr 22;9(8):e157229. doi: 10.1172/jci.insight.157229. JCI Insight. 2024. PMID: 38646935 Free article.
25 results