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STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.
Pencik J, Philippe C, Schlederer M, Atas E, Pecoraro M, Grund-Gröschke S, Li WJ, Tracz A, Heidegger I, Lagger S, Trachtová K, Oberhuber M, Heitzer E, Aksoy O, Neubauer HA, Wingelhofer B, Orlova A, Witzeneder N, Dillinger T, Redl E, Greiner G, D'Andrea D, Östman JR, Tangermann S, Hermanova I, Schäfer G, Sternberg F, Pohl EE, Sternberg C, Varady A, Horvath J, Stoiber D, Malcolm TI, Turner SD, Parkes EE, Hantusch B, Egger G, Rose-John S, Poli V, Jain S, Armstrong CWD, Hoermann G, Goffin V, Aberger F, Moriggl R, Carracedo A, McKinney C, Kennedy RD, Klocker H, Speicher MR, Tang DG, Moazzami AA, Heery DM, Hacker M, Kenner L. Pencik J, et al. Among authors: rose john s. Mol Cancer. 2023 Aug 12;22(1):133. doi: 10.1186/s12943-023-01825-8. Mol Cancer. 2023. PMID: 37573301 Free PMC article.
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation.
Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. Gatsiou A, et al. Among authors: rose john s. Immunity. 2023 May 9;56(5):979-997.e11. doi: 10.1016/j.immuni.2023.03.021. Epub 2023 Apr 25. Immunity. 2023. PMID: 37100060 Free article.
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma.
El-Husseini ZW, Khalenkow D, Lan A, van der Molen T, Brightling C, Papi A, Rabe KF, Siddiqui S, Singh D, Kraft M, Beghe B, van den Berge M, van Gosliga D, Nawijn MC, Rose-John S, Koppelman GH, Gosens R. El-Husseini ZW, et al. Among authors: rose john s. Respir Res. 2023 Dec 7;24(1):308. doi: 10.1186/s12931-023-02617-w. Respir Res. 2023. PMID: 38062491 Free PMC article.
Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy.
Rodríguez-Hernández MÁ, Baena-Bustos M, Carneros D, Zurita-Palomo C, Muñoz-Pinillos P, Millán J, Padillo FJ, Smerdou C, von Kobbe C, Rose-John S, Bustos M. Rodríguez-Hernández MÁ, et al. Among authors: rose john s. EBioMedicine. 2024 Apr 26;103:105132. doi: 10.1016/j.ebiom.2024.105132. Online ahead of print. EBioMedicine. 2024. PMID: 38677182 Free PMC article.
Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity.
Baumgartner F, Bamopoulos SA, Faletti L, Hsiao HJ, Holz M, Gonzalez-Menendez I, Solé-Boldo L, Horne A, Gosavi S, Özerdem C, Singh N, Liebig S, Ramamoorthy S, Lehmann M, Demel U, Kühl AA, Wartewig T, Ruland J, Wunderlich FT, Schick M, Walther W, Rose-John S, Haas S, Quintanilla-Martinez L, Feske S, Ehl S, Glauben R, Keller U. Baumgartner F, et al. Among authors: rose john s. Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20. Sci Signal. 2024. PMID: 38377177
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. Boslem E, et al. Among authors: rose john s. Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703359 Free PMC article.
606 results