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Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.
Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Solon-Biet SM, et al. Among authors: rose aj. Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29. Nat Metab. 2019. PMID: 31656947 Free PMC article.
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution.
Yap YW, Rusu PM, Chan AY, Fam BC, Jungmann A, Solon-Biet SM, Barlow CK, Creek DJ, Huang C, Schittenhelm RB, Morgan B, Schmoll D, Kiens B, Piper MDW, Heikenwälder M, Simpson SJ, Bröer S, Andrikopoulos S, Müller OJ, Rose AJ. Yap YW, et al. Among authors: rose aj. Nat Commun. 2020 Jun 9;11(1):2894. doi: 10.1038/s41467-020-16568-z. Nat Commun. 2020. PMID: 32518324 Free PMC article.
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
Okun JG, Rusu PM, Chan AY, Wu Y, Yap YW, Sharkie T, Schumacher J, Schmidt KV, Roberts-Thomson KM, Russell RD, Zota A, Hille S, Jungmann A, Maggi L, Lee Y, Blüher M, Herzig S, Keske MA, Heikenwalder M, Müller OJ, Rose AJ. Okun JG, et al. Among authors: rose aj. Nat Metab. 2021 Mar;3(3):394-409. doi: 10.1038/s42255-021-00369-9. Epub 2021 Mar 18. Nat Metab. 2021. PMID: 33758419
Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.
Ekim Üstünel B, Friedrich K, Maida A, Wang X, Krones-Herzig A, Seibert O, Sommerfeld A, Jones A, Sijmonsma TP, Sticht C, Gretz N, Fleming T, Nawroth PP, Stremmel W, Rose AJ, Berriel-Diaz M, Blüher M, Herzig S. Ekim Üstünel B, et al. Among authors: rose aj. Nat Commun. 2016 Nov 9;7:13267. doi: 10.1038/ncomms13267. Nat Commun. 2016. PMID: 27827363 Free PMC article.
266 results