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Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Netcharoensirisuk P, Abrahamian C, Tang R, Chen CC, Rosato AS, Beyers W, Chao YK, Filippini A, Di Pietro S, Bartel K, Biel M, Vollmar AM, Umehara K, De-Eknamkul W, Grimm C. Netcharoensirisuk P, et al. Among authors: rosato as. Sci Rep. 2021 Apr 19;11(1):8515. doi: 10.1038/s41598-021-88196-6. Sci Rep. 2021. PMID: 33875769 Free PMC article.
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.
Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S. Yuan Y, et al. Among authors: rosato as. Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0. Nat Commun. 2022. PMID: 35918320 Free PMC article.
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Spix B, Butz ES, Chen CC, Rosato AS, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günsel GG, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García-Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim AÖ, Biel M, Grimm C. Spix B, et al. Among authors: rosato as. Nat Commun. 2022 Jan 14;13(1):318. doi: 10.1038/s41467-021-27860-x. Nat Commun. 2022. PMID: 35031603 Free PMC article.