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Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Sci Rep. 2021 Apr 19;11(1):8515. doi: 10.1038/s41598-021-88196-6.
Sci Rep. 2021.
PMID: 33875769
Free PMC article.
Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.
Rühl P, Rosato AS, Urban N, Gerndt S, Tang R, Abrahamian C, Leser C, Sheng J, Jha A, Vollmer G, Schaefer M, Bracher F, Grimm C.
Rühl P, et al. Among authors: rosato as.
Sci Rep. 2021 Apr 15;11(1):8313. doi: 10.1038/s41598-021-87817-4.
Sci Rep. 2021.
PMID: 33859333
Free PMC article.
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Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes.
Yuan Y, Jaślan D, Rahman T, Bolsover SR, Arige V, Wagner LE 2nd, Abrahamian C, Tang R, Keller M, Hartmann J, Rosato AS, Weiden EM, Bracher F, Yule DI, Grimm C, Patel S.
Yuan Y, et al. Among authors: rosato as.
Nat Commun. 2022 Aug 2;13(1):4481. doi: 10.1038/s41467-022-31959-0.
Nat Commun. 2022.
PMID: 35918320
Free PMC article.
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TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
Krogsaeter E, Rosato AS, Grimm C.
Krogsaeter E, et al. Among authors: rosato as.
Cell Calcium. 2022 May;103:102553. doi: 10.1016/j.ceca.2022.102553. Epub 2022 Feb 5.
Cell Calcium. 2022.
PMID: 35144097
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Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis.
Rosato AS, Tang R, Grimm C.
Rosato AS, et al.
Pharmacol Ther. 2021 Apr;220:107713. doi: 10.1016/j.pharmthera.2020.107713. Epub 2020 Oct 24.
Pharmacol Ther. 2021.
PMID: 33141027
Review.
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Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Spix B, Butz ES, Chen CC, Rosato AS, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günsel GG, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García-Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim AÖ, Biel M, Grimm C.
Spix B, et al. Among authors: rosato as.
Nat Commun. 2022 Jan 14;13(1):318. doi: 10.1038/s41467-021-27860-x.
Nat Commun. 2022.
PMID: 35031603
Free PMC article.
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