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Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.
Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, Cox RD, Richards D, Rorsman P, Thakker RV. Babinsky VN, et al. Among authors: rorsman p. Endocrinology. 2017 Aug 1;158(8):2486-2502. doi: 10.1210/en.2017-00111. Endocrinology. 2017. PMID: 28575322 Free PMC article.
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P. Zhang Q, et al. Among authors: rorsman p. Nat Cell Biol. 2007 Apr;9(4):453-60. doi: 10.1038/ncb1563. Epub 2007 Mar 18. Nat Cell Biol. 2007. PMID: 17369816
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, Nilsson BO, Ohlsson C, Olde B, Leeb-Lundberg LM. Mårtensson UE, et al. Among authors: rorsman p. Endocrinology. 2009 Feb;150(2):687-98. doi: 10.1210/en.2008-0623. Epub 2008 Oct 9. Endocrinology. 2009. PMID: 18845638
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM. Girard CA, et al. Among authors: rorsman p. J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8. J Clin Invest. 2009. PMID: 19065048 Free PMC article.
Exocytotic properties of human pancreatic beta-cells.
Braun M, Ramracheya R, Johnson PR, Rorsman P. Braun M, et al. Among authors: rorsman p. Ann N Y Acad Sci. 2009 Jan;1152:187-93. doi: 10.1111/j.1749-6632.2008.03992.x. Ann N Y Acad Sci. 2009. PMID: 19161389
Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.
Olofsson CS, Håkansson J, Salehi A, Bengtsson M, Galvanovskis J, Partridge C, SörhedeWinzell M, Xian X, Eliasson L, Lundquist I, Semb H, Rorsman P. Olofsson CS, et al. Among authors: rorsman p. Endocrinology. 2009 Jul;150(7):3067-75. doi: 10.1210/en.2008-0475. Epub 2009 Feb 12. Endocrinology. 2009. PMID: 19213846 Free PMC article.
305 results