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Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke.
Belayev L, Obenaus A, Mukherjee PK, Knott EJ, Khoutorova L, Reid MM, Roque CR, Nguyen L, Lee JB, Petasis NA, Oria RB, Bazan NG. Belayev L, et al. Among authors: roque cr. Brain Circ. 2020 Dec 29;6(4):260-268. doi: 10.4103/bc.bc_36_20. eCollection 2020 Oct-Dec. Brain Circ. 2020. PMID: 33506149 Free PMC article.
Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice.
Roque CR, Sampaio LR, Ito MN, Pinto DV, Caminha JSR, Nunes PIG, Raposo RS, Santos FA, Windmöller CC, Crespo-Lopez ME, Alvarez-Leite JI, Oriá RB, Pinheiro RF. Roque CR, et al. Toxicology. 2021 Dec;464:152992. doi: 10.1016/j.tox.2021.152992. Epub 2021 Oct 17. Toxicology. 2021. PMID: 34670124 Free article.
Synergistic Neuroprotection by a PAF Antagonist Plus a Docosanoid in Experimental Ischemic Stroke: Dose-Response and Therapeutic Window.
Reid MM, Obenaus A, Mukherjee PK, Khoutorova L, Roque CR, Petasis NA, Oria RB, Belayev L, Bazan NG. Reid MM, et al. Among authors: roque cr. J Stroke Cerebrovasc Dis. 2022 Aug;31(8):106585. doi: 10.1016/j.jstrokecerebrovasdis.2022.106585. Epub 2022 Jun 17. J Stroke Cerebrovasc Dis. 2022. PMID: 35717719 Free PMC article.
Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice.
Nascimento TS, Pinto DV, Dias RP, Raposo RS, Nunes PIG, Roque CR, Santos FA, Andrade GM, Viana JL, Fostier AH, Sussulini A, Alvarez-Leite JI, Fontes-Ribeiro C, Malva JO, Oriá RB. Nascimento TS, et al. Among authors: roque cr. Int J Mol Sci. 2022 Nov 10;23(22):13837. doi: 10.3390/ijms232213837. Int J Mol Sci. 2022. PMID: 36430321 Free PMC article.
The soluble guanylate cyclase stimulator, 1-nitro-2-phenylethane, reverses monocrotaline-induced pulmonary arterial hypertension in rats.
Gonzaga-Costa K, Roque CR, Vasconcelos-Silva AA, Sousa-Brito HL, Martins CS, Caetano-Souza MM, Duarte GP, da Silva JKR, Borges RS, Dos Santos AA, Magalhães PJC, Lahlou S. Gonzaga-Costa K, et al. Among authors: roque cr. Life Sci. 2021 Jun 15;275:119334. doi: 10.1016/j.lfs.2021.119334. Epub 2021 Mar 9. Life Sci. 2021. PMID: 33711391