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Plugged into the Ku-DNA hub: The NHEJ network.
Frit P, Ropars V, Modesti M, Charbonnier JB, Calsou P. Frit P, et al. Among authors: ropars v. Prog Biophys Mol Biol. 2019 Oct;147:62-76. doi: 10.1016/j.pbiomolbio.2019.03.001. Epub 2019 Mar 6. Prog Biophys Mol Biol. 2019. PMID: 30851288 Review.
Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner.
Vartak SV, Swarup HA, Gopalakrishnan V, Gopinatha VK, Ropars V, Nambiar M, John F, Kothanahally SKS, Kumari R, Kumari N, Ray U, Radha G, Dinesh D, Pandey M, Ananda H, Karki SS, Srivastava M, Charbonnier JB, Choudhary B, Mantelingu K, Raghavan SC. Vartak SV, et al. Among authors: ropars v. FEBS J. 2018 Nov;285(21):3959-3976. doi: 10.1111/febs.14661. Epub 2018 Oct 8. FEBS J. 2018. PMID: 30230716 Free article.
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nemoz C, Ropars V, Frit P, Gontier A, Drevet P, Yu J, Guerois R, Pitois A, Comte A, Delteil C, Barboule N, Legrand P, Baconnais S, Yin Y, Tadi S, Barbet-Massin E, Berger I, Le Cam E, Modesti M, Rothenberg E, Calsou P, Charbonnier JB. Nemoz C, et al. Among authors: ropars v. Nat Struct Mol Biol. 2018 Oct;25(10):971-980. doi: 10.1038/s41594-018-0133-6. Epub 2018 Oct 5. Nat Struct Mol Biol. 2018. PMID: 30291363 Free PMC article.
Modular Imaging Scaffold for Single-Particle Electron Microscopy.
Aissaoui N, Lai-Kee-Him J, Mills A, Declerck N, Morichaud Z, Brodolin K, Baconnais S, Le Cam E, Charbonnier JB, Sounier R, Granier S, Ropars V, Bron P, Bellot G. Aissaoui N, et al. Among authors: ropars v. ACS Nano. 2021 Mar 23;15(3):4186-4196. doi: 10.1021/acsnano.0c05113. Epub 2021 Feb 15. ACS Nano. 2021. PMID: 33586425
The Multifaceted Roles of Ku70/80.
Zahid S, Seif El Dahan M, Iehl F, Fernandez-Varela P, Le Du MH, Ropars V, Charbonnier JB. Zahid S, et al. Among authors: ropars v. Int J Mol Sci. 2021 Apr 16;22(8):4134. doi: 10.3390/ijms22084134. Int J Mol Sci. 2021. PMID: 33923616 Free PMC article. Review.
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL. Chaplin AK, et al. Among authors: ropars v. Mol Cell. 2021 Aug 19;81(16):3400-3409.e3. doi: 10.1016/j.molcel.2021.07.005. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352203 Free PMC article.
PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Andreani J, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK. Seif-El-Dahan M, et al. Among authors: ropars v. Sci Adv. 2023 Jun 2;9(22):eadg2834. doi: 10.1126/sciadv.adg2834. Epub 2023 May 31. Sci Adv. 2023. PMID: 37256950 Free PMC article.
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB. Kefala Stavridi A, et al. Among authors: ropars v. Nucleic Acids Res. 2023 Nov 27;51(21):11732-11747. doi: 10.1093/nar/gkad863. Nucleic Acids Res. 2023. PMID: 37870477 Free PMC article.
37 results