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The Notch pathway regulates the bone gain induced by PTH anabolic signaling.
Delgado-Calle J, McAndrews K, Wu G, Orr AL, Ferrari A, Tu X, Srinivasan V, Roodman GD, Ebetino FH, Boeckman RK Jr, Bellido T. Delgado-Calle J, et al. Among authors: roodman gd. FASEB J. 2022 Mar;36(3):e22196. doi: 10.1096/fj.202101807R. FASEB J. 2022. PMID: 35137455 Free PMC article.
Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity.
Sabol HM, Ferrari AJ, Adhikari M, Amorim T, McAndrews K, Anderson J, Vigolo M, Lehal R, Cregor M, Khan S, Cuevas PL, Helms JA, Kurihara N, Srinivasan V, Ebetino FH, Boeckman RK Jr, Roodman GD, Bellido T, Delgado-Calle J. Sabol HM, et al. Among authors: roodman gd. Cancer Res. 2021 Oct 1;81(19):5102-5114. doi: 10.1158/0008-5472.CAN-21-0524. Epub 2021 Aug 4. Cancer Res. 2021. PMID: 34348968 Free PMC article.
Role of osteocytes in multiple myeloma bone disease.
Delgado-Calle J, Bellido T, Roodman GD. Delgado-Calle J, et al. Among authors: roodman gd. Curr Opin Support Palliat Care. 2014 Dec;8(4):407-13. doi: 10.1097/SPC.0000000000000090. Curr Opin Support Palliat Care. 2014. PMID: 25289928 Free PMC article. Review.
Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma.
Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Delgado-Calle J, et al. Among authors: roodman gd. Cancer Res. 2016 Mar 1;76(5):1089-100. doi: 10.1158/0008-5472.CAN-15-1703. Epub 2016 Feb 1. Cancer Res. 2016. PMID: 26833121 Free PMC article.
Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo.
Miyagawa K, Ohata Y, Delgado-Calle J, Teramachi J, Zhou H, Dempster DD, Subler MA, Windle JJ, Chirgwin JM, Roodman GD, Kurihara N. Miyagawa K, et al. Among authors: roodman gd. JCI Insight. 2020 Mar 26;5(6):e133113. doi: 10.1172/jci.insight.133113. JCI Insight. 2020. PMID: 32078587 Free PMC article.
Pathogenesis of myeloma bone disease.
Roodman GD. Roodman GD. J Cell Biochem. 2010 Feb 1;109(2):283-91. doi: 10.1002/jcb.22403. J Cell Biochem. 2010. PMID: 20014067
296 results