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VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.
Rossini L, Hashimoto Y, Suzuki H, Kurita M, Gianfriddo M, Scali C, Roncarati R, Franceschini D, Pollio G, Trabalzini L, Terstappen GC, Matsuoka M, Caricasole A. Rossini L, et al. Among authors: roncarati r. FASEB J. 2011 Jun;25(6):1983-2000. doi: 10.1096/fj.10-163535. Epub 2011 Mar 10. FASEB J. 2011. PMID: 21393573
Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.
Pollio G, Hoozemans JJ, Andersen CA, Roncarati R, Rosi MC, van Haastert ES, Seredenina T, Diamanti D, Gotta S, Fiorentini A, Magnoni L, Raggiaschi R, Rozemuller AJ, Casamenti F, Caricasole A, Terstappen GC. Pollio G, et al. Among authors: roncarati r. Neurobiol Dis. 2008 Jul;31(1):145-58. doi: 10.1016/j.nbd.2008.04.004. Epub 2008 Apr 29. Neurobiol Dis. 2008. PMID: 18571100
Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C, Zanelli U, Ghiron C, Haydar S, Dunlop J, Terstappen GC. Roncarati R, et al. J Pharmacol Exp Ther. 2009 May;329(2):459-68. doi: 10.1124/jpet.108.150094. Epub 2009 Feb 17. J Pharmacol Exp Ther. 2009. PMID: 19223665
A reporter assay for target validation in primary neuronal cultures.
Pollio G, Roncarati R, Seredenina T, Terstappen GC, Caricasole A. Pollio G, et al. Among authors: roncarati r. J Neurosci Methods. 2008 Jul 15;172(1):34-7. doi: 10.1016/j.jneumeth.2008.03.018. Epub 2008 Apr 7. J Neurosci Methods. 2008. PMID: 18485484
Screening technologies for ion channel drug discovery.
Terstappen GC, Roncarati R, Dunlop J, Peri R. Terstappen GC, et al. Among authors: roncarati r. Future Med Chem. 2010 May;2(5):715-30. doi: 10.4155/fmc.10.180. Future Med Chem. 2010. PMID: 21426199 Review.
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U. Ghiron C, et al. Among authors: roncarati r. J Med Chem. 2010 Jun 10;53(11):4379-89. doi: 10.1021/jm901692q. J Med Chem. 2010. PMID: 20465311
60 results