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Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.
Biochem Soc Trans. 2017 Feb 8;45(1):147-154. doi: 10.1042/BST20160392.
Biochem Soc Trans. 2017.
PMID: 28202668
Review.
The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
Rivero-Ríos P, Romo-Lozano M, Madero-Pérez J, Thomas AP, Biosa A, Greggio E, Hilfiker S.
Rivero-Ríos P, et al. Among authors: romo lozano m.
J Biol Chem. 2019 Mar 29;294(13):4738-4758. doi: 10.1074/jbc.RA118.005008. Epub 2019 Feb 1.
J Biol Chem. 2019.
PMID: 30709905
Free PMC article.
Item in Clipboard
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Lara Ordónez AJ, Fernández B, Fdez E, Romo-Lozano M, Madero-Pérez J, Lobbestael E, Baekelandt V, Aiastui A, López de Munaín A, Melrose HL, Civiero L, Hilfiker S.
Lara Ordónez AJ, et al. Among authors: romo lozano m.
Hum Mol Genet. 2019 Nov 1;28(21):3552-3568. doi: 10.1093/hmg/ddz201.
Hum Mol Genet. 2019.
PMID: 31428781
Free PMC article.
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Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations.
Rivero-Ríos P, Romo-Lozano M, Fernández B, Fdez E, Hilfiker S.
Rivero-Ríos P, et al. Among authors: romo lozano m.
Cells. 2020 Jul 17;9(7):1719. doi: 10.3390/cells9071719.
Cells. 2020.
PMID: 32709066
Free PMC article.
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LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis.
Rivero-Ríos P, Romo-Lozano M, Fasiczka R, Naaldijk Y, Hilfiker S.
Rivero-Ríos P, et al. Among authors: romo lozano m.
Front Neurosci. 2020 Jun 4;14:556. doi: 10.3389/fnins.2020.00556. eCollection 2020.
Front Neurosci. 2020.
PMID: 32581693
Free PMC article.
Review.
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